Results 51 to 60 of about 21,196 (261)

ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases

Journal of Pharmacology and Experimental Therapeutics, 2021
Thymic stromal lymphopoietin (TSLP), positioned at the top of the inflammatory cascade, is a key regulator that enhances allergic inflammatory responses by activating T helper type 2 cells, Group 2 innate lymphoid cells (ILC2), and myeloid dendritic ...
M. Numazaki, Masaki Abe, K. Hanaoka, E. Imamura, M. Maeda, A. Kimura, Jun Miyanohara, Tetsu Saito, K. Arai, Hiroshi Suzuki, Y. Saita   +10 more
semanticscholar   +1 more source

Thymic stromal lymphopoietin and allergic disease [PDF]

Journal of Allergy and Clinical Immunology, 2012
The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways, and gastrointestinal tract.
openaire   +2 more sources

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +9 more sources

Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects [PDF]

, 2012
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases.
Claus Bachert, Luo Zhang, Xiaohong Song, Yanming Zhao, Yuan Zhang   +4 more
core   +2 more sources

Thymic stromal lymphopoietin and alarmins as possible therapeutical targets for asthma

Current Opinion in Allergy and Clinical Immunology, 2021
Purpose of review Overview of epithelial cytokines, particularly thymic stromal lymphopoietin (TSLP), released by the airway epithelium and the effects of their inhibition on the outcomes of patients with asthma.
L. Salvati, L. Maggi, F. Annunziato, L. Cosmi   +3 more
semanticscholar   +1 more source

The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]

, 2013
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler, Florence, Roan, Bryan D, Bell, Thomas A, Stoklasek, Masayuki, Kitajima, Hongwei, Han   +5 more
openaire   +2 more sources

Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj   +1 more source

Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells [PDF]

The Journal of Immunology, 2011
Abstract Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis. TSLP acts on multiple lineages, including dendritic cells (DCs), T cells, NKT cells, eosinophils, and mast cells, mediating proliferation and survival and linking innate and adaptive ...
Mohit, Kashyap, Yrina, Rochman, Rosanne, Spolski, Leigh, Samsel, Warren J, Leonard   +4 more
openaire   +2 more sources

Sebaceous gland rich skin is characterized by TSLP expression and distinct immune surveillance which is disturbed in rosacea [PDF]

, 2017
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Bácsi, Attila, Béke, Gabriella, Bíró, Tamás, Dajnoki, Zsolt, Gáspár, Krisztián, Hendrik, Zoltán, Juhász, István, Kapitány, Anikó, Mócsai, Gábor, Rühl, Ralph, Szegedi, Andrea, Töröcsik, Dániel, Zouboulis, Christos C.   +12 more
core   +1 more source

Elevated Plasma Thymic Stromal Lymphopoietin After Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundThymic stromal lymphopoietin (TSLP), a distant paralog of the cytokine IL-7, has been shown to be associated with atherosclerosis. However, the effect of plasma TSLP level after acute myocardial infarction (AMI) remains largely unclear.
Yuhao Zhao, Yeping Zhang, Zongsheng Guo, Zheng Ma, Ye Liu, Chunming Han, Xinchun Yang, Lei Zhao   +7 more
doaj   +1 more source