Results 81 to 90 of about 16,647 (226)

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

A New Itch to Scratch for TSLP [PDF]

, 2014
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD.
Turner, Matthew J., Zhou, Baohua
core   +1 more source

Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation [PDF]

Immunity, 2013
Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern-recognition receptor (PRR)-expressing HSCs, EMH, and immune responses to microbial stimuli.
Siracusa, Mark C., Saenz, Steven A., Tait Wojno, Elia D., Kim, Brian S., Osborne, Lisa C., Ziegler, Carly G., Benitez, Alain J., Ruymann, Kathryn R., Farber, Donna L., Sleiman, Patrick M., Hakonarson, Hakon, Cianferoni, Antonella, Wang, Mei-Lun, Spergel, Jonathan M., Comeau, Michael R., Artis, David   +15 more
openaire   +2 more sources

IL-23 Induces Atopic Dermatitis-Like Inflammation Instead of Psoriasis-Like Inflammation in CCR2-Deficient Mice [PDF]

, 2013
Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis.
Bromley, Shannon, Larson, Ryan P., Luster, Andrew David, Ziegler, Steven F.   +3 more
core   +2 more sources

Functions of thymic stromal lymphopoietin in immunity and disease [PDF]

Immunologic Research, 2012
Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naïve CD4(+) T cell and activate ...
Yanlu, Zhang, Baohua, Zhou
openaire   +2 more sources

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Environmental effect on health: Air pollution and smoke

Environmental Disease, 2016
This review has discussed various topics related to environmental health. The major findings highlighted are air pollution, children and adult vulnerability, cytokines related to interleukin-33, thymic stromal lymphopoietin, tobacco smoke related to ...
Marianne Frieri, Krishan Kumar, Anthony Boutin   +2 more
doaj   +1 more source

Alternaria-induced release of IL-18 from damaged airway epithelial cells: an NF-κB dependent mechanism of Th2 differentiation? [PDF]

, 2012
Background: A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays a critical role in the pathogenesis of allergic asthma.
Murai, Hiroki, Qi, Huibin, Choudhury, Barun, Wild, Jim, Dharajiya, Nilesh, Vaidya, Swapnil, Kalita, Anjana, Bacsi, Attila, Corry, David, Kurosky, Alexandar, Brasier, Allan, Boldogh, Istvan, Sur, Sanjiv   +12 more
core   +1 more source

Thymic stromal lymphopoietin: master switch for allergic inflammation [PDF]

The Journal of Experimental Medicine, 2006
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers dendritic cell–mediated T helper (Th)2 inflammatory responses. TSLP is highly expressed by keratinocytes in skin lesions of patients with atopic dermatitis and is associated with dendritic cell activation in situ, suggesting that TSLP might be a master switch for ...
openaire   +2 more sources

Thymic stromal lymphopoietin and the pathophysiology of atopic disease [PDF]

Expert Review of Clinical Immunology, 2009
Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiation and progression of allergic ...
Michael M, Miazgowicz, Mark B, Headley, Ryan P, Larson, Steven F, Ziegler   +3 more
openaire   +2 more sources