Results 1 to 10 of about 200,662 (303)

Unveiling Palmitoyl Thymidine Derivatives as Antimicrobial/Antiviral Inhibitors: Synthesis, Molecular Docking, Dynamic Simulations, ADMET, and Assessment of Protein–Ligand Interactions [PDF]

Pharmaceuticals
Background/Objectives: Nucleoside precursors and derivatives play pivotal roles in the development of antimicrobial and antiviral therapeutics. The 2022 global outbreak of monkeypox (Mpox) across more than 100 nonendemic countries underscores the urgent ...
Sarkar M. A. Kawsar, Samiah Hamad Al-mijalli, Gassoumi Bouzid, Emad M. Abdallah, Noimul H. Siddiquee, Mohammed A. Hosen, Mabrouk Horchani, Houcine Ghalla, Hichem B. Jannet, Yuki Fujii, Yasuhiro Ozeki   +10 more
doaj   +2 more sources

Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection [PDF]

Molecular Metabolism
Objective: Viral infection of cells leads to metabolic changes, but how viral infection changes whole-body and tissue metabolism in vivo has not been comprehensively studied. In particular, it is unknown how metabolism might be differentially affected by
Caroline R. Bartman, Shengqi Hou, Fabian Correa, Yihui Shen, Victoria da Silva-Diz, Maya Aleksandrova, Daniel Herranz, Joshua D. Rabinowitz, Andrew M. Intlekofer   +8 more
doaj   +2 more sources

THYMIDINE DEGRADATION PRODUCTS IN PLANT TISSUES LABELED WITH TRITIATED THYMIDINE [PDF]

The Journal of Cell Biology, 1963
A study of the metabolic pathways of H3-thymidine utilization in buds of Lilium longiflorum and root tips of Vicia faba was undertaken in order to obtain information that might explain the binding of H3 from H3-thymidine in the cytoplasm of these plants.
Stephen T. Takats, R.M.S. Smellie
openalex   +4 more sources

Pathways of thymidine hypermodification [PDF]

Nucleic Acids Research, 2021
Abstract The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic.
Yan-Jiun Lee, Nan Dai, Stephanie I Müller, Chudi Guan, Mackenzie J Parker, Morgan E Fraser, Shannon E Walsh, Janani Sridar, Andrew Mulholland, Krutika Nayak, Zhiyi Sun, Yu-Cheng Lin, Donald G Comb, Katherine Marks, Reyaz Gonzalez, Daniel P Dowling, Vahe Bandarian, Lana Saleh, Ivan R Corrêa, Peter R Weigele   +19 more
openaire   +3 more sources

Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources

Frontiers in Cellular and Infection Microbiology, 2022
Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M.
Daria V. Evsyutina, Daria V. Evsyutina, Tatiana A. Semashko, Tatiana A. Semashko, Maria A. Galyamina, Sergey I. Kovalchuk, Rustam H. Ziganshin, Valentina G. Ladygina, Gleb Y. Fisunov, Gleb Y. Fisunov, Olga V. Pobeguts   +10 more
doaj   +1 more source

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
doaj   +1 more source

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Molecules, 2022
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning   +9 more
doaj   +1 more source

Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]

Journal of Biological Chemistry, 2002
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A, MARTI R, NISHINO I, ANDREU AL, NAINI A, TADESSE S, PELA, IVANA, ZAMMARCHI, ENRICO, DONATI MA, OLIVER JA, HIRANO M.   +10 more
openaire   +7 more sources

Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]

Journal of Clinical Microbiology, 1983
Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
F. A. Fralish, S. J. Ressel, Richard B. Tenser, John C. Jones   +3 more
openaire   +3 more sources

Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

Molecules, 2020
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix.
Cláudia D. Raposo, Cristiano A. Conceição, M. Teresa Barros   +2 more
doaj   +1 more source