Results 1 to 10 of about 199,261 (304)
THYMIDINE DEGRADATION PRODUCTS IN PLANT TISSUES LABELED WITH TRITIATED THYMIDINE [PDF]
The Journal of Cell Biology, 1963 A study of the metabolic pathways of H3-thymidine utilization in buds of Lilium longiflorum and root tips of Vicia faba was undertaken in order to obtain information that might explain the binding of H3 from H3-thymidine in the cytoplasm of these plants.
S. T. Takats, R. M. S. Smellie
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Pathways of thymidine hypermodification [PDF]
Nucleic Acids Research, 2021 Abstract The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic.
Yan-Jiun Lee +19 more
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Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]
Journal of Clinical Microbiology, 1983 Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
F. A. Fralish +3 more
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Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates [PDF]
Applied and Environmental Microbiology, 1990 One assumption made in bacterial production estimates from [3H]thymidine incorporation is that all heterotrophic bacteria can incorporate exogenous thymidine into DNA. Heterotrophic marine bacterium isolates from Tampa Bay, Fla., Chesapeake Bay, Md., and a coral surface microlayer were examined for thymidine uptake (transport), thymidine incorporation,
Wade H. Jeffrey, John H. Paul
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Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]
Journal of Biological Chemistry, 2002 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A +10 more
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INDUCIBILITY OF THYMIDINE KINASE BY THYMIDINE AS A FUNCTION OF INTERPHASE STAGE [PDF]
The Journal of Cell Biology, 1965 Thymidine may act as an inducer of thymidine kinase activity in cells of higher plants. The general response is demonstrable in a randomly developing cell population such as is found in germinating wheat embryos. If a synchronously developing cell population is studied, however, potentially inducible cells are found to be susceptible to the inductive ...
Yasuo Hotta, Herbert Stern
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Assessment of Thymidine Phosphorylase Function: Measurement of Plasma Thymidine (and Deoxyuridine) and Thymidine Phosphorylase Activity [PDF]
, 2011 We describe detailed methods to measure thymidine (dThd) and deoxyuridine (dUrd) concentrations and thymidine phosphorylase (TP) activity in biological samples. These protocols allow the detection of TP dysfunction in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Ramon Martí +3 more
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Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2‐mutated fibroblasts [PDF]
The FEBS Journal, 2009 Mitochondrial thymidine kinase (TK2) catalyzes the phosphorylation of thymidine in mitochondria. Its function becomes essential for dTTP synthesis in noncycling cells, where cytosolic dTTP synthesis via R1/R2 ribonucleotide reductase and thymidine kinase 1 is turned down.
FRANGINI, MIRIAM +6 more
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Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]
Biochemical Pharmacology, 2010 Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V. +8 more
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In vivo labeling of fission yeast DNA with thymidine and thymidine analogs [PDF]
Methods, 2004 In vivo labeling of DNA with thymidine and thymidine analogs has long been a cornerstone of replication studies. Unfortunately, yeast lack a thymidine salvage pathway and thus do not incorporate exogenous thymidine. Specifically, yeast neither efficiently take up exogenous thymidine from their growth media nor phosphorylate it to thymidylate, the ...
Sivakumar, Sasirekha +4 more
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