Results 1 to 10 of about 312,982 (289)

A sulfur-containing nucleoside antibiotic from Photorhabdus [PDF]

mBio
We report the discovery of 4′-thiothymidine (4′sT), a sulfur-containing nucleoside antibiotic produced by the nematode symbiont Photorhabdus asymbiotica.
Sangkeun Son, Negar Shahsavari, Thomas Privalsky, Bryson A. Hawkins, Mi-Hyun Lee, Norman Pitt, Akira Iinishi, Raleb Taher, Nikita Gupta, Chandra Sekar Shankar, Jaini Patel, Kim Lewis   +11 more
doaj   +2 more sources

Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection [PDF]

Molecular Metabolism
Objective: Viral infection of cells leads to metabolic changes, but how viral infection changes whole-body and tissue metabolism in vivo has not been comprehensively studied. In particular, it is unknown how metabolism might be differentially affected by
Caroline R. Bartman, Shengqi Hou, Fabian Correa, Yihui Shen, Victoria da Silva-Diz, Maya Aleksandrova, Daniel Herranz, Joshua D. Rabinowitz, Andrew M. Intlekofer   +8 more
doaj   +2 more sources

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
doaj   +1 more source

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Molecules, 2022
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning   +9 more
doaj   +1 more source

Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources

Frontiers in Cellular and Infection Microbiology, 2022
Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M.
Daria V. Evsyutina, Daria V. Evsyutina, Tatiana A. Semashko, Tatiana A. Semashko, Maria A. Galyamina, Sergey I. Kovalchuk, Rustam H. Ziganshin, Valentina G. Ladygina, Gleb Y. Fisunov, Gleb Y. Fisunov, Olga V. Pobeguts   +10 more
doaj   +1 more source

Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]

Journal of Clinical Microbiology, 1983
Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
R B, Tenser, J C, Jones, S J, Ressel, F A, Fralish   +3 more
openaire   +2 more sources

Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

Molecules, 2020
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix.
Cláudia D. Raposo, Cristiano A. Conceição, M. Teresa Barros   +2 more
doaj   +1 more source

Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates [PDF]

Applied and Environmental Microbiology, 1990
One assumption made in bacterial production estimates from [3H]thymidine incorporation is that all heterotrophic bacteria can incorporate exogenous thymidine into DNA. Heterotrophic marine bacterium isolates from Tampa Bay, Fla., Chesapeake Bay, Md., and a coral surface microlayer were examined for thymidine uptake (transport), thymidine incorporation,
W H, Jeffrey, J H, Paul
openaire   +2 more sources

Thymidine kinase 1 through the ages: a comprehensive review

Cell & Bioscience, 2020
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter, M. Townsend, R. Erickson, Carolyn Allen, K. O’Neill   +4 more
semanticscholar   +1 more source

Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]

Journal of Biological Chemistry, 2002
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A, MARTI R, NISHINO I, ANDREU AL, NAINI A, TADESSE S, PELA, IVANA, ZAMMARCHI, ENRICO, DONATI MA, OLIVER JA, HIRANO M.   +10 more
openaire   +5 more sources