Results 131 to 140 of about 127,095 (220)

Total Breakthrough Strategy in Hydrophilic Interaction Chromatography for IP‐RPLC × HILIC Separation of Oligonucleotides

Journal of Separation Science, Volume 49, Issue 3, March 2026.
ABSTRACT Solvent mismatch between the two dimensions is one of the main limitations in two‐dimensional liquid chromatography (2D‐LC) and presents a significant challenge for method development. Although 2D‐LC provides a powerful means to increase peak capacity for oligonucleotides analysis compared to conventional one‐dimensional LC, solvent ...
Megane K. Aebischer, Yusraa Abdurahman, Davy Guillarme   +2 more
wiley   +1 more source

EMT-induced stem cell and mesenchymal programs can be decoupled via cell division and ESRP1-dependent mechanisms. [PDF]

iScience
den Hollander P, Castaneda M, Vasaikar SV, Maddela JJ, Gould C, Demestichas BR, Joseph R, Agarwal S, Deshmukh AP, Zia A, Shah S, Zhou T, Raja G, Allegakoen P, Kuburich NA, Pietila M, Fu C, Chang J, Creighton CJ, Symmans WF, Soundararajan R, Mani SA.   +21 more
europepmc   +1 more source

Gene Editing and Transformation Strategies for Engineering Drought‐Tolerant Legumes

Legume Science, Volume 8, Issue 1, March 2026.
ABSTRACT Legumes play a vital role in agriculture, nutrition, and the economy, but their production faces significant threats. Among these, drought and its unpredictability will be the most damaging constraint in the coming decades. Enhancing drought tolerance is essential for resilient and sustainable legume cultivation, and genetic engineering ...
Andrea Fernandez‐Gutierrez, Shaun J. Curtin, Juan J. Gutierrez‐Gonzalez   +2 more
wiley   +1 more source

Mitotic BLM functions are required to maintain genomic stability. [PDF]

Nucleic Acids Res
Hamann TE, Wieland A, Mohseni F, Vukušić K, Tirincsi A, Wardenaar R, Losito M, Harmsen I, Gönenc II, Wollnik B, Foijer F, Tolić IM, Storchová Z, Räschle M.   +13 more
europepmc   +1 more source

Uptake of Prochlorococcus‐derived metabolites by Alteromonas macleodii MIT1002 shows high levels of substrate specificity

Limnology and Oceanography Letters, Volume 11, Issue 2, March 2026.
Abstract Seawater contains small biomolecules, or metabolites, that are highly labile components of dissolved organic matter (DOM). Marine microbes interact by exchanging metabolites, thus shaping marine microbial ecology, DOM composition, and global carbon cycling.
Kathryn H. Halloran, Rogier Braakman, Allison Coe, Gretchen Swarr, Melissa C. Kido Soule, Sallie W. Chisholm, Elizabeth B. Kujawinski   +6 more
wiley   +1 more source

CldU sensitizes <i>BRCA2</i> reverse-mutated cells to PARP inhibitors. [PDF]

Front Oncol
Zouggari N, Trugenberger C, Du Bois V, Wang W, Rossetti GG, Halazonetis TD, Labidi-Galy I.   +6 more
europepmc   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

The fluoropyrimidine polymer CF10 synergizes with 5-ethynyl-2'-deoxyuridine by promoting telomere attrition and mitotic catastrophe. [PDF]

NAR Mol Med
Das U, Behl A, Gmeiner WH.
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source