Results 11 to 20 of about 127,095 (220)

α-Tocopherol phosphate as a photosensitizer in the reaction of nucleosides with UV light: formation of 5,6-dihydrothymidine

Genes and Environment, 2022
Introduction α-Tocopherol phosphate, a natural water-soluble α-tocopherol analog, exists in biological tissues and fluids. Synthesized α-tocopherol phosphate is used as an ingredient of cosmetics.
Toshinori Suzuki, Chiaki Ono
doaj   +1 more source

Pathways of thymidine hypermodification [PDF]

Nucleic Acids Research, 2021
Abstract The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic.
Yan-Jiun Lee, Nan Dai, Stephanie I Müller, Chudi Guan, Mackenzie J Parker, Morgan E Fraser, Shannon E Walsh, Janani Sridar, Andrew Mulholland, Krutika Nayak, Zhiyi Sun, Yu-Cheng Lin, Donald G Comb, Katherine Marks, Reyaz Gonzalez, Daniel P Dowling, Vahe Bandarian, Lana Saleh, Ivan R Corrêa, Peter R Weigele   +19 more
openaire   +2 more sources

Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]

PLoS ONE, 2018
INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
doaj   +1 more source

A critical examination of substoichiometric isotope dilution analysis using thymidine and leucine

Scientia Marina, 1999
Isotope dilution analysis is used to determine the specific activity of radiolabelled precursors such as 3H-thymidine and 3H-leucine incorporated into DNA or protein in environmental samples.
David F. Bird
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Nitrogen and carbon limitation of planktonic primary production and phytoplankton–bacterioplankton coupling in ponds on the McMurdo Ice Shelf, Antarctica

Environmental Research Letters, 2013
We compared planktonic primary and secondary production across twenty meltwater ponds on the surface of the McMurdo Ice Shelf in January 2007, including some ponds with basal brines created by meromictic stratification.
Brian K Sorrell, Ian Hawes, Karl Safi
doaj   +1 more source

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

Cell Reports, 2017
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama   +20 more
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Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

Beilstein Journal of Organic Chemistry, 2020
In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli uridine
Julia N. Artsemyeva, Ekaterina A. Remeeva, Tatiana N. Buravskaya, Irina D. Konstantinova, Roman S. Esipov, Anatoly I. Miroshnikov, Natalia M. Litvinko, Igor A. Mikhailopulo   +7 more
doaj   +1 more source

Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]

PLoS ONE, 2017
Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim, Yukako Minami, Daiki Tanaka, Shinobu Ukimori, Johanne M Murray, Masaru Ueno   +5 more
doaj   +1 more source

Optimisation of the lymphocyte proliferation assay in rainbow trout (Oncorhynchus mykiss)

Veterinární Medicína, 2019
The lymphocyte proliferation assay is a valuable method used for the evaluation of the fish immune system. However, there are many variations and optimal results are not always obtained.
Hana Minarova, Miroslava Palikova, Jan Mares, Eva Syrova, Jana Blahova, Martin Faldyna, Petra Ondrackova   +6 more
doaj   +1 more source

Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study.

PLoS ONE, 2021
Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage
Antonio Mancini, Francesco Guidi, Carmine Bruno, Flavia Angelini, Edoardo Vergani, Paola Lanza, Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini   +8 more
doaj   +1 more source