Results 11 to 20 of about 199,261 (304)

Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources

Frontiers in Cellular and Infection Microbiology, 2022
Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M.
Daria V. Evsyutina, Daria V. Evsyutina, Tatiana A. Semashko, Tatiana A. Semashko, Maria A. Galyamina, Sergey I. Kovalchuk, Rustam H. Ziganshin, Valentina G. Ladygina, Gleb Y. Fisunov, Gleb Y. Fisunov, Olga V. Pobeguts   +10 more
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α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
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The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Molecules, 2022
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning   +9 more
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Thymidine kinase 1 through the ages: a comprehensive review

Cell & Bioscience, 2020
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter, M. Townsend, R. Erickson, Carolyn Allen, K. O’Neill   +4 more
semanticscholar   +1 more source

Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

Molecules, 2020
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix.
Cláudia D. Raposo, Cristiano A. Conceição, M. Teresa Barros   +2 more
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Interaction of Thymidine with Sodium bis(2-ethylhexyl) Sulfosuccinate in Alcohol and Water: Studies with UV-Vis Technique

Pharmaceutical Sciences and Research, 2020
The accurate measurement of thymidine absorbance in the presence of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in ethanol and water systems at room temperature by UV-vis technique has been reported.
Indu M. Paudel, Ajaya Bhattarai
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Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

Beilstein Journal of Organic Chemistry, 2020
In the present work, we suggested anion exchange resins in the phosphate form as a source of phosphate, one of the substrates of the phosphorolysis of uridine, thymidine, and 1-(β-ᴅ-arabinofuranosyl)uracil (Ara-U) catalyzed by recombinant E. coli uridine
Julia N. Artsemyeva, Ekaterina A. Remeeva, Tatiana N. Buravskaya, Irina D. Konstantinova, Roman S. Esipov, Anatoly I. Miroshnikov, Natalia M. Litvinko, Igor A. Mikhailopulo   +7 more
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α-Tocopherol phosphate as a photosensitizer in the reaction of nucleosides with UV light: formation of 5,6-dihydrothymidine

Genes and Environment, 2022
Introduction α-Tocopherol phosphate, a natural water-soluble α-tocopherol analog, exists in biological tissues and fluids. Synthesized α-tocopherol phosphate is used as an ingredient of cosmetics.
Toshinori Suzuki, Chiaki Ono
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Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]

PLoS ONE, 2018
INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
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Deoxynucleoside Therapy for Thymidine Kinase 2–Deficient Myopathy

Annals of Neurology, 2019
Thymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in childhood
C. Domínguez-González, M. Madruga‐Garrido, F. Mavillard, C. Garone, F. J. Aguirre-Rodríguez, M. Donati, K. Kleinsteuber, I. Martí, E. Martín‐Hernández, Juan P Morealejo-Aycinena, F. Munell, A. Nascimento, S. Kalko, M. D. Sardina, C. Álvarez del Vayo, Olga Serrano, Yuelin Long, Yuqi Tu, B. Levin, John L.P. Thompson, K. Engelstad, J. Uddin, J. Torres-Torronteras, C. Jiménez-Mallebrera, R. Martí, C. Paradas, M. Hirano   +26 more
semanticscholar   +1 more source