Results 251 to 260 of about 151,527 (300)
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Cancer, 1980
This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
D S, Martin +6 more
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This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
D S, Martin +6 more
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Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase [PDF]
Bioorganic and Medicinal Chemistry, 2011 International audienceWe report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives.
Hélène Munier-Lehmann +2 more
exaly +2 more sources
The thymidine phosphorylating kinases
Biochimica et Biophysica Acta, 1961Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI +3 more
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Feedback inhibition of thymidine kinase by thymidine triphosphate
Experimental Cell Research, 1963THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
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Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
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Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
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Nature, 1960
IN the course of a series of experiments designed to test for possible anomalies in the synthesis and behaviour of chromosomal deoxyribonucleic acid resulting from the use of tritiated thymidine, the possibility arose that the tritiated precursor could interfere with the normal course of synthesis and partition by destroying the integrity of the ...
M, KRAUSE, W, PLAUT
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IN the course of a series of experiments designed to test for possible anomalies in the synthesis and behaviour of chromosomal deoxyribonucleic acid resulting from the use of tritiated thymidine, the possibility arose that the tritiated precursor could interfere with the normal course of synthesis and partition by destroying the integrity of the ...
M, KRAUSE, W, PLAUT
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Radiation effects of thymidine-3H and thymidine-14C
Experimental Cell Research, 1960Results are reported from a comparative study of the fequencies of chromosome aberrations induced by tritiumgroup and in the number two position of the pyrimidine ring, C/sup 14/ in the methyl group produced twice as many abberations as C/sup 14/ in the pyrimidine ring. (auth)
H.A. McQuade, M. Friedkin
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The association of thymidine kinase activity and thymidine transport in Escherichia coli
Gene, 1991We have constructed a series of mutants within the putative nucleoside-binding site of the herpes simplex type-1 virus (HSV-1) thymidine kinase (TK)-encoding gene (tk), contained within an expression vector. While most mutations within this sequence produce an inactive protein, we find no absolute requirement for the wild-type Ile166 and Ala167.
D K, Dube, M S, Horwitz, L A, Loeb
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Preparation of 4‘-Substituted Thymidines by Substitution of the Thymidine 5‘-Esters
The Journal of Organic Chemistry, 2001tert-Butyl thymidylate 3 was prepared from thymidine 1 in six steps and 67% overall yield. When the lithium trianion of 3 (prepared by treatment of 3 with excess LDA and then excess tert-butyllithum) is reacted with electrophiles, trapping occurs stereoselectively from either the alpha- or beta-face depending on the electrophile (Scheme 1 ...
M E, Jung, A, Toyota
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Determination of the Absolute P‐Configuration of a Phthalidyl‐Phosphonate Thymidine‐Thymidine Dimer
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
W, Fendrich, C, Meier
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