Results 241 to 250 of about 232,266 (302)

An Effect of Tritiated Thymidine on the Incorporation of Thymidine into Chromosomal Deoxyribonucleic Acid

Nature, 1960
IN the course of a series of experiments designed to test for possible anomalies in the synthesis and behaviour of chromosomal deoxyribonucleic acid resulting from the use of tritiated thymidine, the possibility arose that the tritiated precursor could interfere with the normal course of synthesis and partition by destroying the integrity of the ...
M, KRAUSE, W, PLAUT
openaire   +2 more sources

Radiation effects of thymidine-3H and thymidine-14C

Experimental Cell Research, 1960
Results are reported from a comparative study of the fequencies of chromosome aberrations induced by tritiumgroup and in the number two position of the pyrimidine ring, C/sup 14/ in the methyl group produced twice as many abberations as C/sup 14/ in the pyrimidine ring. (auth)
H.A. McQuade, M. Friedkin
openaire   +1 more source

The association of thymidine kinase activity and thymidine transport in Escherichia coli

Gene, 1991
We have constructed a series of mutants within the putative nucleoside-binding site of the herpes simplex type-1 virus (HSV-1) thymidine kinase (TK)-encoding gene (tk), contained within an expression vector. While most mutations within this sequence produce an inactive protein, we find no absolute requirement for the wild-type Ile166 and Ala167.
D K, Dube, M S, Horwitz, L A, Loeb
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Preparation of 4‘-Substituted Thymidines by Substitution of the Thymidine 5‘-Esters

The Journal of Organic Chemistry, 2001
tert-Butyl thymidylate 3 was prepared from thymidine 1 in six steps and 67% overall yield. When the lithium trianion of 3 (prepared by treatment of 3 with excess LDA and then excess tert-butyllithum) is reacted with electrophiles, trapping occurs stereoselectively from either the alpha- or beta-face depending on the electrophile (Scheme 1 ...
M E, Jung, A, Toyota
openaire   +2 more sources

Determination of the Absolute P‐Configuration of a Phthalidyl‐Phosphonate Thymidine‐Thymidine Dimer

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
W, Fendrich, C, Meier
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Thymidine

2000
Abstract Thymidine, a naturally occurring nucleoside, has been extensively investigated as a single agent in cancer chemo therapy and as a biochemical modulator for cytotoxic drugs such a 5-fluorouracil (5-FU), methotrexate, and cytarabine. It is an hypothesis that thymidine can expand intracellular desoxynucleoside triphosphate pools,
openaire   +1 more source

α‐Thymidin

Chemische Berichte, 1960
AbstractDie Kondensation von Monoquecksilberthymin mit Di‐p‐toluyl‐desoxy‐D‐ribofuranosylchlorid führt vorwiegend zum α‐Thymidinderivat, wenn man sie in stark polaren Verdünnungsmitteln wie Dimethylformamid ausführt. Daß es sich nicht um eine Kondensation am N‐3 des Thymins handelt, kann durch Methylierung des Produktes am N‐3 gezeigt werden.
openaire   +1 more source

A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay.

JIM - Journal of Immunological Methods, 1994
S. Ansar Ahmed, R. Gogal, J. E. Walsh
semanticscholar   +1 more source

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Cell, 1977
Michael, Wigler, Saul, Silverstein, Lih-Syng, Lee, Ángel, Pellicer, Yung-chi, Cheng   +9 more
semanticscholar   +1 more source

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.

Science, 1999
I. Nishino, A. Spinazzola, M. Hirano
semanticscholar   +1 more source