Results 231 to 240 of about 232,266 (302)

Thymidine-Inosine Dimer Building Block for Reversible Modification of Synthetic Oligonucleotides. [PDF]

Molecules
Kolganova NA, Varizhuk IV, Stomakhin AA, Khisamov MM, Solyev PN, Surzhikov SA, Timofeev EN.   +6 more
europepmc   +1 more source

Pyrimidine nucleoside: inspiration for novel antimicrobial agent. [PDF]

Front Pharmacol
Xu B, Li P, Liu J, Li M.
europepmc   +1 more source

Thymidine Kinase Diversity in Bacteria [PDF]

Nucleosides, Nucleotides and Nucleic Acids, 2006
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related
Sandrini, Michael P., Clausen, Anders R., Munch-Petersen, Birgitte, Piskur, Jure   +3 more
openaire   +4 more sources

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Thymidine incorporation as a measure of heterotrophic bacterioplankton production in marine surface waters: Evaluation and field results

Marine Biology, 1982
Jed Fuhrman, Farooq Azam, Azam F
exaly   +2 more sources

An overview of thymidine

Cancer, 1980
This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
D S, Martin, R L, Stolfi, R C, Sawyer, R, Nayak, S, Spiegelman, C W, Young, T, Woodcock   +6 more
openaire   +2 more sources

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase [PDF]

Bioorganic and Medicinal Chemistry, 2011
International audienceWe report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives.
Hélène Munier-Lehmann, Serge Van Calenbergh, Matheus Froeyen   +2 more
exaly   +3 more sources

The thymidine phosphorylating kinases

Biochimica et Biophysica Acta, 1961
Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI, J A, BUTLER, A R, CRATHORN, K V, SHOOTER   +3 more
openaire   +2 more sources

The dual role of thymidine phosphorylase in cancer development and chemotherapy

Medicinal Research Reviews, 2009
Thymidine phosphorylase (TP), also known as “platelet‐derived endothelial cell growth factor” (PD‐ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers. TP promotes tumor growth and metastasis
Annelies Bronckaers, Federico Gago
exaly   +2 more sources

Feedback inhibition of thymidine kinase by thymidine triphosphate

Experimental Cell Research, 1963
THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
openaire   +2 more sources

Thymidine Kinases in Archaea

Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen, A, Matakos, M P B, Sandrini, J, Piskur   +3 more
openaire   +2 more sources