Results 261 to 270 of about 199,261 (304)

An overview of thymidine

Cancer, 1980
This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
Sol Spiegelman, Robert L. Stolfi, R Nayak, Daniel S. Martin, Robert C. Sawyer, Thomas M. Woodcock, Charles W. Young   +6 more
openaire   +3 more sources

Prior exposure to thymidine analogs and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors

AIDS (London), 2019
Background: Thymidine analogs and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous adipose tissue (SAT) to visceral adipose tissue (VAT), which, in turn, is a risk factor for cardiovascular disease.
M. Gelpi, S. Afzal, A. Fuchs, J. Lundgren, A. Knudsen, Ninna Drivsholm, A. Mocroft, A. Lebech, Birgitte Lindegaard, J. T. Kühl, P. Sigvardsen, L. Køber, B. Nordestgaard, K. Kofoed, S. Nielsen   +14 more
semanticscholar   +1 more source

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.

Science, 1999
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (mtDNA), which have been ascribed to a defect in communication between the ...
I. Nishino, A. Spinazzola, M. Hirano
semanticscholar   +1 more source

The thymidine phosphorylating kinases

Biochimica et Biophysica Acta, 1961
Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P.A. Bianchi, J. A. V. Butler, A.R. Crathorn, K.V. Shooter   +3 more
openaire   +4 more sources

Adaptive response of human lymphocytes to low concentrations of radioactive thymidine.

Science, 1984
When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the
G. Olivieri, J. Bodycote, S. Wolff
semanticscholar   +1 more source

Feedback inhibition of thymidine kinase by thymidine triphosphate

Experimental Cell Research, 1963
THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
openaire   +3 more sources

Radiation effects of thymidine-3H and thymidine-14C

Experimental Cell Research, 1960
Results are reported from a comparative study of the fequencies of chromosome aberrations induced by tritiumgroup and in the number two position of the pyrimidine ring, C/sup 14/ in the methyl group produced twice as many abberations as C/sup 14/ in the pyrimidine ring. (auth)
M. Friedkin, M. Friedkin, H.A. McQuade, H.A. McQuade   +3 more
openaire   +2 more sources

Thymidine Kinases in Archaea

Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
Michael P. B. Sandrini, Anders R. Clausen, Jure Piškur, A Matakos   +3 more
openaire   +3 more sources

Specification of cerebral cortical areas.

Science, 1988
How the immense population of neurons that constitute the human cerebral neocortex is generated from progenitors lining the cerebral ventricle and then distributed to appropriate layers of distinctive cytoarchitectonic areas can be explained by the ...
P. Rakic
semanticscholar   +1 more source

Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.

Journal of the National Cancer Institute, 1990
Retroviral vectors constructed to contain the herpes simplex virus thymidine kinase (HSV-TK) gene were used for transduction of this gene into murine sarcoma and lymphoma cells to yield sublines susceptible in vitro to the cytotoxicity of ganciclovir, a ...
F. Moolten, J. M. Wells
semanticscholar   +1 more source