Results 21 to 30 of about 199,261 (304)
Cell Synchronization by Double Thymidine Block.
Bio-protocol, 2018 Cell synchronization is widely used in studying mechanisms involves in regulation of cell cycle progression. Through synchronization, cells at distinct cell cycle stage could be obtained.
Guo Chen, Xingming Deng
semanticscholar +1 more source
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival
Cell Reports, 2017 Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata +20 more
doaj +1 more source
Environmental Research Letters, 2013 We compared planktonic primary and secondary production across twenty meltwater ponds on the surface of the McMurdo Ice Shelf in January 2007, including some ponds with basal brines created by meromictic stratification.
Brian K Sorrell, Ian Hawes, Karl Safi
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Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]
PLoS ONE, 2017 Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim +5 more
doaj +1 more source
Optimisation of the lymphocyte proliferation assay in rainbow trout (Oncorhynchus mykiss)
Veterinární Medicína, 2019 The lymphocyte proliferation assay is a valuable method used for the evaluation of the fish immune system. However, there are many variations and optimal results are not always obtained.
Hana Minarova +6 more
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A critical examination of substoichiometric isotope dilution analysis using thymidine and leucine
Scientia Marina, 1999 Isotope dilution analysis is used to determine the specific activity of radiolabelled precursors such as 3H-thymidine and 3H-leucine incorporated into DNA or protein in environmental samples.
David F. Bird
doaj +1 more source
PLoS ONE, 2021 Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage
Antonio Mancini +8 more
doaj +1 more source
Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions. [PDF]
PLoS ONE, 2016 Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2',4'-position of the ribose with the inclusion of a bridge,
Sung-Kun Kim +5 more
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Cancer Discovery, 2013 UNLABELLED The ornithine decarboxylase inhibitor α-difluoromethylornithine (DFMO) is a highly effective chemopreventive agent for colorectal cancer thought to act via polyamine depletion. However, in DFMO-treated patients, mucosal polyamine levels do not
Mavee Witherspoon +4 more
semanticscholar +1 more source
Frontiers in Pediatrics, 2022 BackgroundPatients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT).
Hsin-Ju Lee +13 more
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