Results 51 to 60 of about 946,060 (233)

Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence

Aging Cell, Volume 24, Issue 4, April 2025.
Senescence inducing stimuli leads to large‐cluster hypercondensed DNA globules. This architectural phenomenon is associated with geographically clustered transcriptional repression. Such large‐scale clustered silencing of chromosomal segments may drive deep senescence through two possible ways: (1) one or more critical combination of genes, for example
Aditi U. Gurkar, Satoshi Okawa, Christelle Guillermier, Kritika Chaddha, Matthew L. Steinhauser   +4 more
wiley   +1 more source

Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses.

The Journal of pharmacy and pharmacology, 2008
The effect of anise oil, dwarf-pine oil and chamomile oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined.
C. Koch, J. Reichling, R. Kehm, M. Sharaf, H. Zentgraf, Jürgen Schneele, P. Schnitzler   +6 more
semanticscholar   +2 more sources

Urotensin II-induced signaling involved in proliferation of vascular smooth muscle cells

Vascular Health and Risk Management, 2010
Myriam Iglewski, Stephen R GrantDepartment of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, USAAbstract: The urotensin II receptor, bound by the ligand urotensin II, generates second ­messengers, ie ...
Myriam Iglewski, Stephen R Grant
doaj  

Development of a genetic sensor that eliminates p53 deficient cells

Nature Communications, 2017
TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene ...
Jovan Mircetic, Antje Dietrich, Maciej Paszkowski-Rogacz, Mechthild Krause, Frank Buchholz   +4 more
doaj   +1 more source

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.

Biochemistry, 2009
Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1). Whereas TK1 is only responsible for thymidine phosphorylation, dCK is capable of converting dC, dA, and dG into their ...
Saugata Hazra, E. Sabini, S. Ort, M. Konrad, A. Lavie   +4 more
semanticscholar   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Down regulation by a low-zinc diet in gene expression of rat prostatic thymidylate synthase and thymidine kinase

Nutrition & Metabolism, 2008
Background Zinc has a wide spectrum of biological activities and its deficiency is related to various abnormalities of cell metabolism. Methods Wistar male rats, at age of 4 weeks, were fed a low-zinc diet for six weeks.
Sassa Shuji, Nemoto Nahoko, Suzuki Satoe, Kudo Hideki, Ishikawa Yuko, Sakamoto Shinobu   +5 more
doaj   +1 more source

Pregnancy in women with mitochondrial disease—A literature review and suggested guidance for preconception and pregnancy care

Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 65, Issue 1, Page 30-36, February 2025.
Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women.
Lisa Hui, Pema Hayman, Ali Buckland, Michael C Fahey, David A Mackey, Andrew J Mallett, Daniel R Schweitzer, Clare P Stuart, Wai Yan Yau, John Christodoulou   +9 more
wiley   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

An Adenovirus Vector Containing the Suicide Gene Thymidine Kinase for a Broad Application in Cancer Gene Therapy

Memorias do Instituto Oswaldo Cruz, 2002
Treatment of cancer using gene therapy is based on adding a property to the cell leading to its elimination. One possibility is the use of suicide genes that code for enzymes that transform a pro-drug into a cytotoxic product.
GS Magalhães, AR Muotri, MCN Marchetto, CFM Menck, AM Ventura   +4 more
doaj   +1 more source