Results 51 to 60 of about 62,555 (239)

Repetitive Imaging of Reporter Gene Expression in the Lung

Molecular Imaging, 2003
Positron emission tomographic imaging is emerging as a powerful technology to monitor reporter transgene expression in the lungs and other organs. However, little information is available about its usefulness for studying gene expression over time ...
Jean-Christophe Richard, Philip Factor, Thomas Ferkol, Datta E. Ponde, Zhaohui Zhou, Daniel P. Schuster   +5 more
doaj   +1 more source

Electrophoresis of Adenovirus-Specified Thymidine Kinase [PDF]

Journal of Virology, 1969
Stimulation of thymidine kinase (TK) activity occurs after abortive or productive infection with human adenoviruses. Striking changes in TK electrophoretic profile accompany this stimulation.
Raymond V. Gilden, Edda Twiddy, Masakazu Hatanaka   +2 more
openaire   +3 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Development of a genetic sensor that eliminates p53 deficient cells

Nature Communications, 2017
TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene ...
Jovan Mircetic, Antje Dietrich, Maciej Paszkowski-Rogacz, Mechthild Krause, Frank Buchholz   +4 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Down regulation by a low-zinc diet in gene expression of rat prostatic thymidylate synthase and thymidine kinase

Nutrition & Metabolism, 2008
Background Zinc has a wide spectrum of biological activities and its deficiency is related to various abnormalities of cell metabolism. Methods Wistar male rats, at age of 4 weeks, were fed a low-zinc diet for six weeks.
Sassa Shuji, Nemoto Nahoko, Suzuki Satoe, Kudo Hideki, Ishikawa Yuko, Sakamoto Shinobu   +5 more
doaj   +1 more source

Thymidine Kinase Activity in Dictyostelium discoideum [PDF]

Microbiology, 1980
Thymidine kinase activity is present in soluble and mitochondrial fraction of axenically grown cells of Dictyostelium discoideum. The overall activity does not change significantly during development.
R. A. Deering, C. A. Michrina
openaire   +3 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

An ecological framework for microbial metabolites in the ocean ecosystem

Limnology and Oceanography Letters, EarlyView.
Abstract The ocean microbe‐metabolite network involves thousands of individual metabolites that encompass a breadth of chemical diversity and biological functions. These microbial metabolites mediate biogeochemical cycles, facilitate ecological relationships, and impact ecosystem health. While analytical advancements have begun to illuminate such roles,
Bryndan P. Durham, Winifred M. Johnson, Catherine C. Bannon, Erin M. Bertrand, Anitra E. Ingalls, Bethanie R. Edwards, Amy Apprill, Angela K. Boysen, Randelle M. Bundy, Huan Chen, Frank X. Ferrer‐González, Cara Fiore, Katherine R. Heal, Constanze Kuhlisch, Shuting Liu, Kaijun Lu, Laurel E. Meke, Sammy Pontrelli, Prabavathy Vaiyapuri Ramalingam, Alicia M. Reigel, Joshua S. Sacks, Jeremy E. Schreier, Jegan Sekar, Mario Uchimiya, Elizabeth B. Kujawinski   +24 more
wiley   +1 more source

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications

ChemistryOpen, EarlyView.
This review highlights the emerging applications of molecularly imprinted polymers (MIPs) in bone regeneration and diagnosis. MIPs facilitate osteogenic treatments by guiding stem cell differentiation and delivering bioactive molecules and enable precise detection of bone turnover biomarkers via MIP‐based sensors, offering promising strategies for next‐
Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y. S. Chau, Jonathan C. Knowles, Feng Peng, Alessandro Poma   +8 more
wiley   +1 more source