Results 61 to 70 of about 116,563 (263)
Thymidine Kinase in IDU Resistance.
Experimental Biology and Medicine, 1965 SummaryStudies were done to determine whether 5-iodo-2′-deoxyuridine resistance of herpes simplex in rabbit corneal infection was a function of thymidine kinase deficiency in the viral genome. Herpes simplex virus passed in rabbit kidney cells in the presence of 5-iodo-2′-deoxyuridine was resistant to it in vivo although this resistant virus induced ...
Y, Centifanto, H E, Kaufman
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Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency
EMBO Molecular Medicine, 2014 Autosomal recessive mutations in the thymidine kinase 2 gene (TK2) cause mitochondrial DNA depletion, multiple deletions, or both due to loss of TK2 enzyme activity and ensuing unbalanced deoxynucleotide triphosphate (dNTP) pools.
Caterina Garone +8 more
doaj +1 more source
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]
, 1987 Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core
Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]
, 2003 While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore +3 more
core +5 more sources
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Passatempo Virus, a Vaccinia Virus Strain, Brazil
Emerging Infectious Diseases, 2005 Passatempo virus was isolated during a zoonotic outbreak. Biologic features and molecular characterization of hemagglutinin, thymidine kinase, and vaccinia growth factor genes suggested a vaccinia virus infection, which strengthens the idea of the ...
Juliana A. Leite +11 more
doaj +1 more source
EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets
Advanced Science, EarlyView.Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang +4 more
wiley +1 more source
Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]
, 2010 Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D. +3 more
core +1 more source
Increased Serum Thymidine Kinase following Chemotherapy [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1999 Thymidine kinase (TK, EC 2.7.1.21) is considered a salvage enzyme of DNA synthesis and is associated with the G liS phase of dividing cells.' Serum TK concentration is considered to be a guide to the proliferative state, and increases in TK activity appear to correlate with progression of human neoplasia.I?
A, Akbay, S, Demirtaş, Y, Yavuz
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