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Thymidine Phosphorylase in Cancer; Enemy or Friend? [PDF]

Cancer Microenviron, 2016
Thymidine phosphorylase (TP) is a nucleoside metabolism enzyme that plays an important role in the pyrimidine pathway.TP catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Although this reaction is reversible, the main metabolic function of TP is catabolic.
Elamin YY, Rafee S, Osman N, O Byrne KJ, Gately K.   +4 more
europepmc   +6 more sources

TYMP (thymidine phosphorylase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on TYMP (thymidine phosphorylase), with data on DNA, on the protein encoded, and where the gene is implicated.
Bijnsdorp, IV, Peters, GJ
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Thymidine phosphorylase and uridine phosphorylase of Lactobacillus casei [PDF]

FEMS Microbiology Letters, 1988
Crude extracts of Lactobacillus casei, were found to possess both thymidine phosphorylase and uridine phosphorylase activities, which were associated with a single sucrose gradient band. However, using dye ligand chromatography (Green A), two enzymatic fractions were obtained each of which possessed mainly one of these activities.
Yosefa Avraham, Jacob Yashphe, Nathan Grossowicz   +2 more
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Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]

Biochemical Pharmacology, 2010
Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V., Azijli, K., Jansen, E.E.W., Wamelink, M.M.C., Jakobs, C., Struijs, E.A., Fukushima, M, Kruyt, F.A.E., Peters, G.J.   +8 more
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Assessment of Thymidine Phosphorylase Function: Measurement of Plasma Thymidine (and Deoxyuridine) and Thymidine Phosphorylase Activity [PDF]

, 2011
We describe detailed methods to measure thymidine (dThd) and deoxyuridine (dUrd) concentrations and thymidine phosphorylase (TP) activity in biological samples. These protocols allow the detection of TP dysfunction in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Ramon Martí, Ramon Martí, Michio Hirano, Luis C. López   +3 more
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Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]

Journal of Biological Chemistry, 2002
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A, MARTI R, NISHINO I, ANDREU AL, NAINI A, TADESSE S, PELA, IVANA, ZAMMARCHI, ENRICO, DONATI MA, OLIVER JA, HIRANO M.   +10 more
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Thymidine phosphorylase expression in Kaposi sarcoma. [PDF]

Journal of Clinical Pathology, 1996
AIMS: To examine the immunohistochemical distribution of thymidine phosphorylase (TP) in all clinicopathological subtypes of Kaposi sarcoma. METHODS: Thirty two biopsy specimens of Kaposi sarcoma (29 patients) were studied. Six of these patients represented classic, six endemic, eight HIV associated, seven post-immunosuppression/transplant related, and
Johann W. Schneider, M.A. Dada, K C Gatter, M Comley, Runjan Chetty, C H Boshoff, Helen Turley   +6 more
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The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase

European Journal of Pharmacology, 2004
Thymidine phosphorylase (platelet-derived-endothelial-cell-growth-factor) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate, activates 5'-deoxy-5-fluorouridine (5'DFUR) and inactivates trifluorothymidine (TFT).
de Bruin, M., van Capel, T, Smid, K., Fukushima, M, Hoekman, K., Pinedo, H.M., Peters, G.J.   +6 more
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Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase [PDF]

Journal of the American Chemical Society, 2010
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, and its action promotes angiogenesis. In the absence of phosphate, hTP catalyzes a slow hydrolytic depyrimidination of dT yielding thymine and 2-deoxyribose (dRib).
Phillip A. Schwartz, Vern L. Schramm, Mathew J. Vetticatt   +2 more
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The cytosol activity of thymidine phosphorylase in endometrial cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor samples from patients with endometrial cancer.The activity of TP was measured by the spectrophotometric method in the cytosol of endometrial tumor
Andrzej Bieńkiewicz, Jacek Bartkowiak, Robert Kubiak, Elżbieta Miszczak-Zaborska   +3 more
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