Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
Tümidiini fosforülaasi ekspressiooni analüüsi rakendamine metastaatilise neeruvähiga patsientide kasvajakoes [PDF]
, 2006 Tümidiini fosforülaas on ensüüm, mis muundab kapetsitabiini inaktiivsed metaboliidid aktiivseks ravimiks 5-fluorouratsiiliks. Kuna tümidiini fosforülaasi kontsentratsioonid kasvajakoes on suured, aktiveerub kapetsitabiin eelistatult kasvajakolletes ...
Leppik, Krista +2 more
core +2 more sources
Thymidine phosphorylase: A potential new target for treating cardiovascular disease. [PDF]
Trends Cardiovasc Med, 2018 Li W, Yue H.
europepmc +2 more sources
Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways [PDF]
, 2015 Background High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment.
Liu, Haijuan +5 more
core +2 more sources
The cytosol activity of thymidine phosphorylase in endometrial cancer
Journal of Experimental & Clinical Cancer Research, 2008 Background Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor samples from patients with ...
Bieńkiewicz Andrzej +3 more
doaj +1 more source
Data on proteome of Mycoplasma hominis cultivated with arginine or thymidine as a carbon source
Data in Brief, 2020 Mycoplasma hominis is an opportunistic bacterium that can cause acute and chronic infections of the urogenital tract. This bacterium, like all other Mycoplasma species, is characterized by the reduced genome size, and, consequently, reduction of the main
Tatiana A. Semashko +7 more
doaj +1 more source
Mitochondrial neurogastrointestinal encephalomyopathy in a Pakistani female: a case report
Journal of Medical Case Reports, 2022 Background Mitochondrial neurogastrointestinal encephalopathy is a rare multisystem autosomal recessive disease caused by mutations in the TYMP gene, that encodes for thymidine phosphorylase.
Zaraq Rashid Khan +4 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the association between thymidine phosphorylase(TYMP) polymorphism and clinical outcomes of colorectal cancer(CRC) patients received adjuvant chemotherapy after R0 resection.
ZHANG Yu, HOU Yanhua, ZHANG Dezhi
doaj +1 more source
Radiation recall after capecitabine in a patient with recurrent nasopharyngeal carcinoma: a case report [PDF]
, 2016 published_or_final_versio
Kwong, DLW, Lam, KO, Lee, VHF, Leung, TW
core +1 more source
Journal of Chemistry, 2016 A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat +9 more
doaj +1 more source