Results 1 to 10 of about 74,896 (329)

Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing

Frontiers in Microbiology, 2021
Diminished antibiotic susceptibility of bacterial pathogens is an increasingly serious threat to human and animal health. Alternative strategies are required to combat antibiotic refractory bacteria.
Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu, Kangni Yang, Yuqian Jia, Jingru Shi, Ziwen Tong, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang   +10 more
doaj   +2 more sources

1,3-Bis(2-oxopropyl)thymine [PDF]

IUCrData, 2020
In the title compound [systematic name: 5-methyl-1,3-bis(2-oxopropyl)pyrimidine-2,4(1H,3H)-dione], C11H14N2O4, the two 2-oxopropyl groups are nearly perpendicular to the planar thymine unit. One methyl group of oxopropyl substituent is disordered. In the
Bogdan Doboszewski, Alexander Y. Nazarenko, Fábio da Paixão Soares   +2 more
doaj   +2 more sources

Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA [PDF]

Molecules
Mismatched T:G base pairs can arise during de novo replication as well as base excision repair (BER). In particular, the action of the gap-filling polymerase β (Polβ) can generate a T:G pair as well as a nick in the DNA backbone.
Hala Ouzon-Shubeita, Rebecca Barnes, Lillian F. Schmaltz, Seongmin Lee   +3 more
doaj   +2 more sources

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase [PDF]

PeerJ
Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer ...
Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T. Matkarimov, Dmitry Zharkov, Murat K. Saparbaev, Sabira Taipakova   +8 more
doaj   +3 more sources

A thymine-challenge test to prospectively evaluate dihydropyrimidine dehydrogenase activity for risk of severe 5-fluorouracil-induced gastrointestinal toxicity. [PDF]

Cancer Chemother Pharmacol
Helsby N, Sharples K, Kim YJ, Porter D, Burns K, Jeong SH, Benge S, Deva S, Lawrence B, Jackson C, North R, Strother RM, Duley J, Findlay M.   +13 more
europepmc   +3 more sources

Thy-AuNP-AgNP Hybrid Systems for Colorimetric Determination of Copper (II) Ions Using UV-Vis Spectroscopy and Smartphone-Based Detection

Nanomaterials, 2022
A colorimetric probe based on a hybrid sensing system of gold nanoparticles (AuNPs), silver nanoparticles (AgNPs), and thymine (Thy) was developed for easy and rapid detection of copper (II) ions (Cu2+) in solution. The underlying principle of this probe
Thitiporn Thongkam, Amara Apilux, Thitaporn Tusai, Tewarak Parnklang, Sumana Kladsomboon   +4 more
doaj   +1 more source

Ru-Controlled Thymine Tautomerization Frozen by a k¹(O)-, k²(N,O)-Metallacycle: An Experimental and Theoretical Approach

Molecules, 2023
The reaction of mer-(Ru(H)2(CO)(PPh3)3) (1) with one equivalent of thymine acetic acid (THAcH) unexpectedly produces the macrocyclic dimer k1(O), k2(N,O)-(Ru(CO)(PPh3)2THAc)2 (4) and, concomitantly, the doubly coordinated species k1(O), k2(O,O)-(Ru(CO ...
Silvia Bordoni, Riccardo Tarroni, Magda Monari, Stefano Cerini, Fabio Battaglia, Gabriele Micheletti, Carla Boga, Giacomo Drius   +7 more
doaj   +1 more source

Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb³⁺ Ions in Drinking and Natural Waters

Molecules, 2023
The toxic effects of antimony pose risks to human health. Therefore, simple analytical techniques for its widescale monitoring in water sources are in demand. In this study, a sensitive microplate apta-enzyme assay for Sb3+ detection was developed.
Nadezhda S. Komova, Kseniya V. Serebrennikova, Anna N. Berlina, Anatoly V. Zherdev, Boris B. Dzantiev   +4 more
doaj   +1 more source

An optimized thymine base editing toolkit with various editing windows enables targeted T-to-G base conversions in rice. [PDF]

Plant Biotechnol J
Li X, Tian Y, Shen R, Pang Y, Tang K.
europepmc   +3 more sources

Density Functional Method Study on the Cooperativity of Intermolecular H-bonding and π-π⁺ Stacking Interactions in Thymine-[C_nmim]Br (n = 2, 4, 6, 8, 10) Microhydrates

Molecules, 2022
The exploration of the ionic liquids’ mechanism of action on nucleobase’s structure and properties is still limited. In this work, the binding model of the 1-alkyl-3-methylimidazolium bromide ([Cnmim]Br, n = 2, 4, 6, 8, 10) ionic liquids to the thymine ...
Yanni Wang, Chaowu Dai, Wei Huang, Tingting Ni, Jianping Cao, Jiangmei Pang, Huining Wei, Chaojie Wang   +7 more
doaj   +1 more source