Results 31 to 40 of about 163,535 (332)

Towards a quantitative theory of tolerance [PDF]

arXiv, 2023
A cornerstone of the classical view of tolerance is the elimination of self-reactive T cells during negative selection in the thymus. However, high-throughput T-cell receptor sequencing data has so far failed to detect substantial signatures of negative selection in the observed repertoires.
arxiv  

The Neuropeptides Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Control HIV-1 Infection in Macrophages Through Activation of Protein Kinases A and C

Frontiers in Immunology, 2018
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are highly similar neuropeptides present in several tissues, endowed with immunoregulatory functions and other systemic effects.
Jairo R. Temerozo, Jairo R. Temerozo, Suwellen S. D. de Azevedo, Daniella B. R. Insuela, Rhaíssa C. Vieira, Pedro L. C. Ferreira, Vinícius F. Carvalho, Vinícius F. Carvalho, Gonzalo Bello, Dumith Chequer Bou-Habib, Dumith Chequer Bou-Habib   +10 more
doaj   +1 more source

A new homeostatic model of the T cell system [PDF]

Journal of Biological Systems, 19, 299-317, 2011, 2010
Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeostatic equilibrium with self MHC-self peptide complexes. The homeostatic T cell repertoire can recognize infections non-specifically and this is an indirect (negative) recognition: the whole homeostatic T cell ...
arxiv   +1 more source

Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
We investigated the identity of IL‐15 producing cells using several mouse strains with cell type‐specific loss of IL‐15 expression. After the resolution of acute infection, IL‐15 secreted by regulatory cells, but not skeletal muscles or myeloid cells, was required for the maintenance of a subset of memory cells referred to as terminal effector memory T
Alaa Madi, Jingxia Wu, Sicong Ma, Nina Weisshaar, Alessa Mieg, Marvin Hering, Yanan Ming, Ferdinand Zettl, Kerstin Mohr, Nora ten Bosch, Tilo Schlimbach, Franziska Hertel, Guoliang Cui   +12 more
wiley   +1 more source

Six Spain Thymus essential oils composition analysis and their in vitro and in silico study against Streptococcus mutans

BMC Complementary Medicine and Therapies, 2023
Background Streptococcus mutans is a well-known oral pathogen that plays a critical role in the development of dental caries. Many studies have been directed to discover the chemical compounds present in natural products to inhibit the growth and biofilm
Su-Yeon Park, Rifat Nowshin Raka, Xiu-Li Hui, Yang Song, Jin-Long Sun, Jie Xiang, Juan Wang, Jian-Ming Jin, Xu-Kai Li, Jun-Song Xiao, Hua Wu   +10 more
doaj   +1 more source

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022
Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner, Nikolaus Romani, Christoph Rademacher, Hans Christian Probst, Karsten Mahnke   +4 more
wiley   +1 more source

Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions

Frontiers in Endocrinology, 2018
T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez, Alexandre Morrot, Alexandre Morrot, Vinicius Frias Carvalho, Vinicius Frias Carvalho, Juliana de Meis, Juliana de Meis, Wilson Savino, Wilson Savino   +8 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

CT density of cervical thymus, in comparison with mediastinal thymus

Insights into Imaging, 2019
Objectives Cervical component of thymus is noted more in children and young adults than in older age group. CT texture (lobules of soft tissue interspersed with fat), similarity with CT density of mediastinal thymus and continuity with mediastinal thymus
Anitha Sen, Jiji Valsalamony, Jubie Raj
doaj   +1 more source

Limited sex differences in plastic responses suggest evolutionary conservatism of thermal reaction norms: A meta‐analysis in insects

Evolution Letters, Volume 6, Issue 6, Page 394-411, December 2022., 2022
Abstract Temperature has a profound effect on the growth and development of ectothermic animals. However, the extent to which ecologically driven selection pressures can adjust thermal plastic responses in growth schedules is not well understood. Comparing temperature‐induced plastic responses between sexes provides a promising but underexploited ...
Tiit Teder, Kristiina Taits, Ants Kaasik, Toomas Tammaru   +3 more
wiley   +1 more source