Results 41 to 50 of about 163,535 (332)
BMC Pediatrics, 2021 Background Malnutrition continues to be a major cause of mortality and morbidity among children in resource limited settings. Children with severe acute malnutrition (SAM) experience severe thymus atrophy, possibly reflecting poor immune function.
Nicolette Nabukeera-Barungi +12 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Thymectomy for myasthenia gravis: A pathological analysis
Indian Journal of Pathology and Microbiology, 2022 Background: Myasthenia gravis (MG) is a prototypic T-cell-dependent antibody-mediated autoimmune disease that leads to ocular or generalized muscular weakness.
Shweta Bansod +3 more
doaj +1 more source
How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes [PDF]
Phys. Rev. E 97, 032413 (2018), 2018 T cell receptors (TCRs) bind foreign or self-peptides attached to major histocompatibility complex (MHC) molecules, and the strength of this interaction determines T cell activation. Optimizing the ability of T cells to recognize a diversity of foreign peptides yet be tolerant of self-peptides is crucial for the adaptive immune system to properly ...
arxiv +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 307-319, January 2023., 2023 Electrospinning‐assisted fabrication of gliadin was performed. The effects of processing parameters on morphology and properties were studied. The Zataria multiflora Boiss essential oil (ZMEO) was electro‐encapsulated in the nanofibers. Kinetic modeling on the ZMEO release from gliadin nanofibers was applied.
Zohreh Bahrami +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A bioengineered skin equivalent composed of electrospun poly(ε‐caprolactone) (PCL) and the bioactive peptide Fmoc‐FRGD is developed for severe burn treatment. This scaffold promotes full‐thickness skin regeneration by supporting cellular adhesion and integration. In‐vitro and in‐vivo studies show enhanced mechanical stability, accelerated wound closure,
Dana Cohen‐Gerassi +11 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 364-378, January 2023., 2023 In this paper, the best protein removal method of Lonicera japonica polysaccharide was determined and its process was optimized by response surface method. Pharmacological experiments showed that polysaccharides had therapeutic effect on immunodeficiency mice induced by cyclophosphamide (CTX).
Jie Ding +7 more
wiley +1 more source
Revisiting the Teleost Thymus: Current Knowledge and Future Perspectives
Biology, 2020 The thymus in vertebrates plays a critical role in producing functionally competent T-lymphocytes. Phylogenetically, the thymus emerges early during evolution in jawed cartilaginous fish, and it is usually a bilateral organ placed subcutaneously at the ...
Felipe Barraza +10 more
doaj +1 more source