Results 101 to 110 of about 37,130 (197)

In vitro activities of tigecycline combined with other antimicrobials against multiresistant Gram-positive and Gram-negative pathogens [PDF]

, 2017
Objectives To test the activity of tigecycline combined with 16 antimicrobials in vitro against 22 Gram-positive and 55 Gram-negative clinical isolates. Methods Antibiotic interactions were determined by chequerboard and time-kill methods.
Entenza, José M., Giddey, Marlyse, Moreillon, Philippe, Vouillamoz, Jacques   +3 more
core  

Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections:a multi-country medical chart review in Europe [PDF]

, 2014
BACKGROUND: Patient-related (demographic/disease) and treatment-related (drug/clinician/hospital) characteristics were evaluated as potential predictors of healthcare resource use and opportunities for early switch (ES) from intravenous (IV)-to-oral ...
A Gray, AD Tice, AL Chapman, BA Cunha, BA Lipsky, C Eckmann, C Eckmann, Caitlyn T Solem, Christian Eckmann, Cynthia Macahilig, D Nathwani, D Nathwani, DA Goff, Damien Simoneau, Dilip Nathwani, HS Sader, HT Hatoum, J Edelsberg, Jennifer M Stephens, Jim Z Li, KB Bamford, M Borner, M Desai, M Dryden, M Hensher, P Mladovsky, PC Matthews, RA Seaton, Richard Chambers, S Leekha, S Parodi, SC Lim, Seema Haider, Shelby Corman, TH Dellit, Wendy Lawson   +35 more
core   +4 more sources

Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline

Nature Communications
Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site.
Xiang Li, Mengjiao Wang, Timo Denk, Robert Buschauer, Yi Li, Roland Beckmann, Jingdong Cheng   +6 more
doaj   +1 more source

Evaluating Prescriber Adherence to Guideline-Based Treatment Pathways of a Newly Initiated Antimicrobial Stewardship Program at a Rehabilitation Hospital [PDF]

, 2017
Background: Inappropriate use of antimicrobials in the healthcare setting is associated with consequences including antimicrobial resistance, Clostridium difficile infection (CDI), adverse drug reactions, and increased healthcare costs.
Bertram, Christie
core   +1 more source

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Medicine Science, 2017
Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms.
Yucel Duman, Cigdem Kuzucu, Mehmet Sait Tekerekoglu   +2 more
doaj   +1 more source

Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis [PDF]

, 2017
Objectives Antibiotics are commonly classified into bactericidal and bacteriostatic agents based on their antimicrobial action. We aimed to assess whether this distinction is clinically relevant.
Kuster, Stefan P., Nemeth, Johannes, Oesch, Gabriela   +2 more
core  

Clinical and microbiological analysis of risk factors for breakthrough bloodstream infection during Tigecycline Therapy

Scientific Reports
Background Tigecycline is widely used to treat a variety of bacterial infections despite concerns regarding increased mortality in severe infections.
Sol Jin, So Yun Lim, Yun Woo Lee, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Eun Hee Song, Yong Pil Chong   +13 more
doaj   +1 more source

A promising metabolite, 9-aminominocycline, restores the sensitivity of tigecycline against tet(X4)-positive Escherichia coli

Frontiers in Microbiology
The emergence and widespread of tigecycline resistance undoubtedly poses a serious threat to public health globally. The exploration of combination therapies has become preferred antibacterial strategies to alleviate this global burden.
Feifei Sun, Feifei Sun, Lin Zhang, Xuan Ma, Tariq Ali, Yongning Wu, Lin Li   +6 more
doaj   +1 more source

The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure

Journal of Global Antimicrobial Resistance
: Objectives: We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved. Material and methods: The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res).
Kristin Hegstad, Anna K. Pöntinen, Jørgen V. Bjørnholt, Else Quist-Paulsen, Arnfinn Sundsfjord   +4 more
doaj   +1 more source

Tigecycline [PDF]

Reactions Weekly, 2020
  +4 more sources