Results 81 to 90 of about 26,995 (192)

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation

Aging Cell, Volume 25, Issue 6, June 2026.
Tetracyclines extend lifespan and protect neurons from ferroptosis by attenuating protein synthesis across multiple eukaryotic models through ISR‐dependent or ISR‐independent mechanisms, enabling classification based on their mode of action. ABSTRACT Reducing protein synthesis extends lifespan across taxa, but pharmacological strategies to safely ...
Khalyd J. Clay, Manuel Sanchez‐Alavez, Ian Newman, Na Na, Ana P. Verduzco Espinoza, Alan To, Shannon Saad, Hollis T. Cline, Michael Petrascheck   +8 more
wiley   +1 more source

Bloodstream infection with pandrug-resistant Alcaligenes faecalis treated with double-dose of tigecycline

IDCases, 2019
Introduction: Alcaligenes faecalis is a species of gram-negative, rod-shaped, aerobic bacteria commonly found in the environment. A. faecalis-associated nosocomial infections are common in hospitalized patients, but serious life threatening infections ...
Md Jahidul Hasan, Lutfun Nahar Nizhu, Raihan Rabbani   +2 more
doaj   +1 more source

In-vitro activities of imipenem–colistin, imipenem–tigecycline, and tigecycline–colistin combinations against carbapenem-resistant Enterobacteriaceae*

, 2018
© 2018, © 2018 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia.The aim of the study is to determine in-vitro effects of imipenem–tigecycline, imipenem–colistin and tigecycline–colistin against carbapenem-resistant Enterobacteriaceae (CRE ...
DÜNDAR, DEVRİM, Duymaz, Zehra, ER, DOĞANHAN KADİR, İrvem, Arzu, Genc, SERPİL, Kandemir, Neslisah   +5 more
core   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Development and implementation of a computerised clinical decision support system for hospital‐in‐the‐home patient identification

Internal Medicine Journal, Volume 56, Issue 6, Page 991-1001, June 2026.
ABSTRACT Background Identification of appropriate patients for hospital‐in‐the‐home (HITH) remains a significant challenge. We hypothesise that a human‐centred design (HCD) approach can assist in developing a computerised clinical decision support system (CDSS) to address this issue via leveraging data within the electronic medical record (EMR).
Seok Ming Lim, Thomas Kitt‐Thompson, Douglas Forsyth Johnson, Michael Turner, Adam Boulton, Samantha Plumb, Daniel Capurro, Wen‐Kwang Lim   +7 more
wiley   +1 more source

Tigecycline-amikacin combination effectively suppresses the selection of resistance in clinical isolates of KPC-producing Klebsiella pneumoniae

Frontiers in Microbiology, 2016
By far, only tigecycline, colistin and some aminoglycosides still show favorable in vitro activities against carbapenem-resistant Enterobacteriaceae. However, rapid emergence of resistance often occurs during long-term treatment in clinic, challenging ...
Wentao Ni, Chuanqi Wei, Chufei Zhou, Jin Zhao, Beibei Liang, Junchang Cui, Rui Wang, Youning Liu   +7 more
doaj   +1 more source

Tigecycline treatment in an infant with extensively drug-resistant Acinetobacter baumannii bacteremia

International Journal of Infectious Diseases, 2017
The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented.
Jiawei Zeng, Lidan Zhang, Min Gao, Jingjing Wu, Haiyan Wu, Jie Chen, Xiao Chen, Wen Tang   +7 more
doaj   +1 more source

EUCAST Technical Note on tigecycline

, 2006
Tigecycline is an injectable antibacterial agent derived from the tetracyclines and classified by the manufacturer as a glycylcycline. Tigecycline was registered by the European Medicines Agency (EMEA) in May 2006 for parenteral use in complicated ...
HRYNIEWICZ W., VARALDO, Pietro, RODLOFF A., CANTON R., MACGOWAN A. P., BROWN D. F. J., GOLDSTEIN F., MOUTON J. W., STEINBAKK M., KAHLMETER G., ODENHOLT I.   +10 more
core   +1 more source

Efficacy of intravenous tigecycline in patients with Acinetobacter complex infections: results from 14 Phase III and Phase IV clinical trials

, 2017
Hal Tucker, Michele Wible, Ashesh Gandhi, Alvaro QuintanaPfizer Inc, Collegeville, PA, USABackground: Acinetobacter infections, especially multidrug-resistant (MDR) Acinetobacter infections, are a global health problem.
Tucker H, Quintana A, Wible M, Gandhi A
core  

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Medicine Science, 2017
Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms.
Yucel Duman, Cigdem Kuzucu, Mehmet Sait Tekerekoglu   +2 more
doaj   +1 more source