Results 51 to 60 of about 21,607 (116)

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, Volume 293, Issue 6, Page 1587-1611, March 2026.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Tigecycline Treatment In Critically Ill Children: A Single-Center Experience

Journal of Global Antimicrobial Resistance
AIM: We aimed to draw attention to the fact that tigecycline may be an alternative in the treatment of resistant gram-negative infections in children.
Neslihan Mete Atasever, Elif Dede, Mavera Uşaklıoğlu Erol, Ayper Somer, Selda Hançerli Törün   +4 more
doaj   +1 more source

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for hospital acquired pneumonia

Infectious Disease Reports, 2010
The in vitro activity of tigecycline was evaluated against 819 baseline pathogens isolated from 383 patients enrolled in the phase 3 clinical trial investigating the efficacy of tigecycline in hospital acquired pneumonia (HAP).
Peter J. Petersen, Margareta Tuckman, Hal Jones   +2 more
doaj   +1 more source

Peritoneal Dialysis‐Related Mycobacterium fortuitum Exit‐Site/Tunnel Infection in a Pediatric Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT In patients in peritoneal dialysis (PD) who develop exit site and/or catheter tunnel infections, expeditious identification of the causative organism and early implementation of treatment are important to ensure good outcomes. Among the many causative organisms, the diagnosis of Mycobacterium fortuitum is particularly challenging, with its ...
Rina Takahashi, Hiroshi Tamura, Keishiro Furuie, Hiroko Nagata, Shohei Kuraoka   +4 more
wiley   +1 more source

Antibiotic Resistance, Biofilm Genes, and smeDEF Efflux Pump in Clinical Stenotrophomonas maltophilia Isolates From Iran

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Iranian clinical Stenotrophomonas maltophilia isolates showed high susceptibility to trimethoprim/sulfamethoxazole, minocycline, and levofloxacin, but marked resistance to ceftazidime and ticarcillin‐clavulanate, alongside widespread biofilm production and resistance genes.
Haneen Fadhil Jasim, Nisreen Salah Majeed, Asmaa A. Salam, Rania Hameed Hamad, Yeganeh Behrouzi, Erta Rajabi, Razieh Shahbazi   +6 more
wiley   +1 more source

Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li, Fei Zeng, Jie Zhang, Yuangong Zhang, Wenjuan Yin   +4 more
wiley   +1 more source

Antibiotic resistance mediated by site‐specific mutations in the multidrug efflux transporter CmeB of zoonotic pathogen Campylobacter

mLife, Volume 5, Issue 1, Page 83-98, February 2026.
Abstract The resistance‒nodulation‒division (RND) family of multidrug efflux transporters is widely distributed in Gram‐negative bacteria. Although their roles in mediating antibiotic resistance have been well known, our understanding of how they are altered to augment bacterial adaptation to antibiotic selection remains at an infancy stage.
Xiaolong Lin, Mengyu Zhao, Jianhong Gan, Haozheng Li, Min He, Fang Yang, Renqiao Wen, Tiejun Zhang, Quan Zhou, Ke Wu, Jinpeng Li, Chengyao Hou, Yang Cao, Hongning Wang, Yizhi Tang   +14 more
wiley   +1 more source

Exploring the Potential and Evaluating Hydrocarbon Degradation by Novel Antarctic Dietzia and Pusillimonas Isolates From a Pristine Environment

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
The Antarctic Dietzia and Pusillimonas isolates were tested for bioremediation applications. Genomic analyses revealed the potential to degrade complex organic compounds, potential virulence factors and resistance genes. Physiological assays showed a wide range of adaptation to abiotic factors and sensitivity to different groups of antibiotics ...
Tomasz Krucoń, Julia Karbowska, Wiktoria Pietrowicz, Robert Stasiuk, Łukasz Drewniak   +4 more
wiley   +1 more source

Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain

Antibiotics
Background: This study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR) Acinetobacter baumannii strain.
Cihan Yüksel, Işıl D. Alıravcı, Murat Koşan, Sinem Esen, Sevinç Yenice Aktaş, Neslihan Kaya Terzi, Ahmet Ali Berber, Sevil Alkan, Selçuk Kaya   +8 more
doaj   +1 more source

Bloodstream infection with pandrug-resistant Alcaligenes faecalis treated with double-dose of tigecycline

IDCases, 2019
Introduction: Alcaligenes faecalis is a species of gram-negative, rod-shaped, aerobic bacteria commonly found in the environment. A. faecalis-associated nosocomial infections are common in hospitalized patients, but serious life threatening infections ...
Md Jahidul Hasan, Lutfun Nahar Nizhu, Raihan Rabbani   +2 more
doaj   +1 more source