Results 1 to 10 of about 19,418 (180)
The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline [PDF]
International Journal of Molecular SciencesThe presence of sub-minimal inhibitory concentration (sub-MIC) antibiotics in our environment is widespread, and their ability to induce antibiotic resistance is inevitable. Acinetobacter baumannii, a pathogen known for its strong ability to acquire antibiotic resistance, has recently shown clinical resistance to the last-line antibiotic tigecycline ...
Cunwei Liu +4 more
europepmc +4 more sources
Resistance mechanisms of tigecycline in Acinetobacter baumannii
Frontiers in Cellular and Infection Microbiology, 2023 Acinetobacter baumannii is widely distributed in nature and in hospital settings and is a common pathogen causing various infectious diseases. Currently, the drug resistance rate of A. baumannii has been persistently high, showing a worryingly high resistance rate to various antibiotics commonly used in clinical practice, which greatly limits ...
Chunli Sun +7 more
openaire +4 more sources
Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance [PDF]
Clinical Microbiology and Infection, 2020 Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients.
David van Duin +10 more
openalex +3 more sources
Roles of Salmonella multidrug efflux pumps in tigecycline resistance [PDF]
Journal of Antimicrobial Chemotherapy, 2010 salmonella enterica strains exhibiting decreased susceptibility to tigecycline have been reported. In this study, we sought to elucidate the roles of Salmonella multidrug efflux pumps and AcrAB regulators in tigecycline resistance.we examined the involvement of multidrug efflux pumps and AcrAB regulators in resistance to tigecycline and other ...
Tsukasa Horiyama +3 more
openalex +3 more sources
Tigecycline resistance tet(X3) gene is going wild
Biosafety and Health, 2020 The emergence of mobile Tigecycline-resistant tet(X3) and tet(X4) is believed to be a global threat to public health. Here, we investigated the prevalence of tet(X3) and tet(X4) in our metagenomic data of migratory birds. While tet(X4) was not identified in our samples, tet(X3) was found in two gut microbiomes of bird fecal samples, with 100% amino ...
Jian Cao +6 more
openalex +3 more sources
High tigecycline resistance in multidrug-resistant Acinetobacter baumannii—authors' response [PDF]
Journal of Antimicrobial Chemotherapy, 2007 Shiri Navon‐Venezia +2 more
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A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The increasing incidence of tigecycline resistance undoubtedly constitutes a serious threat to global public health. The combination therapies had become the indispensable strategy against this threat. Herein, 11 clinical tigecycline-resistant Klebsiella pneumoniae which mainly has mutations in ramR, acrR, or macB were collected for tigecycline ...
Lilan Sun +7 more
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High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [PDF]
Journal of Antimicrobial Chemotherapy, 2007 Multidrug-resistant (MDR) Acinetobacter baumannii is increasing in our hospital and worldwide, raising the necessity of finding effective therapies. We aimed to evaluate the in vitro activity of tigecycline against MDR A. baumannii clones isolated before tigecycline was used in our institution.Eighty-two unique patient clinical isolates of multidrug ...
Shiri, Navon-Venezia +2 more
openaire +2 more sources
Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects ...
Linkevicius, Marius +2 more
openaire +3 more sources
Susceptibility of Tigecycline against Carbapenem Resistant Enterobacteriaceae [PDF]
Pakistan Journal of Medicine and Dentistry, 2021 Background: Enterobacteriaceae, a large family of Gram-negative bacteria, are one of the commonest etiological agents causing serious bacterial infections to humans. Carbapenems are the group of antibiotics with a broad spectrum of antimicrobial action.
Madeeha Fatima +2 more
openaire +2 more sources