The tigecycline resistance mechanisms in Gram-negative bacilli [PDF]
Frontiers in Cellular and Infection MicrobiologyTigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli. This study explores the complex mechanisms of tigecycline resistance in Gram-negative bacilli, with a particular focus on the role of efflux pumps and drug ...
Zhiren Wang, Zhiren Wang, Henan Li
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Molecular mechanisms of tigecycline-resistance among Enterobacterales [PDF]
Frontiers in Cellular and Infection MicrobiologyThe global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous microorganisms. This phenomenon poses a serious threat to public health. Notably, the significance of
Lukasz Korczak +9 more
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Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library [PDF]
Antibiotics, 2022 Acinetobacter baumannii is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant A.
Ping Wang +5 more
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Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus [PDF]
Microbiology Spectrum, 2023 Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years.
Honghao Huang +6 more
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A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae [PDF]
Microbiology SpectrumThis study aims to investigate the novel potential tigecycline resistance mechanism in Klebsiella pneumoniae and provide new insights for the clinical treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In vitro experiments were
Yuyao Xu +8 more
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Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp. [PDF]
Microbiology Spectrum, 2022 The appearance and prevalence of novel plasmid-encoded tigecycline resistance efflux pump gene clusters tmexC1D1-toprJ1 and tmexC2D2-toprJ2 in Enterobacteriaceae have raised a threat to public health.
Cheng-Zhen Wang +8 more
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Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides [PDF]
Frontiers in Microbiology, 2021 Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of ...
Hua-le Chen +9 more
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Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China [PDF]
Microbiology Spectrum, 2021 We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang +7 more
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Genetic Determinants of Tigecycline Resistance in Mycobacteroides abscessus [PDF]
Antibiotics, 2022 Mycobacteroides abscessus (formerly Mycobacterium abscessus) is a clinically important, rapid-growing non-tuberculous mycobacterium notoriously known for its multidrug-resistance phenotype. The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression of a tetracycline-degrading enzyme ...
Hien Fuh Ng, Yun Fong Ngeow
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Induction of Tigecycline Resistance in Acinetobacter baumannii
BIO-PROTOCOL, 2014 Multidrug resistance Acinetobacter baumannii (A. baumannii) (MDRAB) has emerged as a serious threat in hospitals in recent years. Currently, there are few antibiotics, including tigecycline, available to treat infections caused by MDRAB effectively.
Ming-Feng Lin, Yun-You Lin, Chung-Yu Lan
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