The Journal of Infection in Developing Countries, 2021 Introduction: Tigecycline is a unique class of semi-synthetic glycylcyclines developed to treat infections caused by multidrug-resistant Klebsiella pneumoniae. In the past decades, eight tigecycline-resistant Acinetobacter baumannii isolates have been identified in Tehran and no Klebsiella pneumoniae has been reported. Methodology: To elucidate ...
Rezvan Goodarzi +4 more
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The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure
Journal of Global Antimicrobial ResistanceWe describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved.The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res). received in 2022 an Enterococcus faecium blood culture isolate with decreased susceptibility to tigecycline from a hospitalized patient in the South-Eastern Norway ...
Kristin Hegstad +4 more
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Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections [PDF]
Microbial Cell FactoriesBackground A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last ...
Jindian Yang# +7 more
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Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli [PDF]
Microbiology SpectrumThe rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report
Jing Sun +14 more
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Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations [PDF]
Frontiers in MicrobiologyIntroductionThe emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.MethodsIn this study, we evaluated the synergism of ...
Juan Liu +22 more
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PLOS ONE, 2015 KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae. To identify the susceptibility profile of KPC-producing K.
Fang He +6 more
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Molecular Analysis of Tigecycline Resistance in Carbapenem-Resistant Enterobacterales (Cre) in Mthatha and Surrounding Hospitals [PDF]
Antibiotics (Basel)Luyolo Vumba +2 more
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Microbiology Spectrum, 2021 Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated tigecycline heteroresistance in A.
Jeongwoo Jo, Kwan Soo Ko
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Disruption of zinc homeostasis reverses tigecycline resistance in Klebsiella pneumoniae [PDF]
Front Cell Infect MicrobiolJinyu Wang +3 more
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Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump tmexC6D6-toprJ1b and tmexCD-toprJ Variants [PDF]
Microbiol Spectr, 2023 Cheng-Zhen Wang +10 more
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