Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2016 : INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years.
Yuhan Yin +4 more
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Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet (X4) in Enterobacterales of Porcine Origin [PDF]
Microbiol Spectr, 2022 Qin Wang +8 more
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Synergistic Role of Biofilm-Associated Genes and Efflux Pump Genes in Tigecycline Resistance of Acinetobacter baumannii [PDF]
Med Sci Monit, 2023 Bin Luo +3 more
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Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis
Frontiers in Veterinary Science, 2021 The aim of this study was to gain insight into the resistance determinants conferring resistance to tigecycline in Streptococcus (S.) suis and to investigate the genetic elements involved in their horizontal transfer. A total of 31 tetracycline-resistant
Rui Yu +6 more
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Emerging Microbes and Infections, 2021 Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A.
Xiaoting Hua +12 more
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Confronting Tigecycline-Resistant Acinetobacter baumannii via Immunization Against Conserved Resistance Determinants [PDF]
Frontiers in Microbiology, 2020 Antimicrobial-resistant (AMR) bacterial infections, including those caused by Acinetobacter baumannii, have emerged as a clinical crisis worldwide. Immunization with AMR determinants has been suggested as a novel approach to combat AMR bacteria, but has not been validated.
Ming-Hsien Chiang +10 more
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Occurrence and mechanisms of tigecycline resistance in carbapenem- and colistin-resistant Klebsiella pneumoniae in Thailand [PDF]
Sci RepNachat Chirabhundhu +6 more
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Tigecycline: pharmacological concerns and resistance
International Journal of Basic & Clinical Pharmacology, 2020 Tigecycline, a semisynthetic derivative of minocycline, has a broad spectrum of activity against both gram positive and gram negative multidrug resistant bacteria. The drug acts on 30S ribosomal subunit and inhibits protein synthesis. Since the drug has excellent tissue distribution, it is very useful for treatment of skin infections, intra-abdominal ...
Rama Paudel, Hari P. Nepal
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Microbiology Spectrum, 2022 Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii
Jiangang Zhang +8 more
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Identification of novel tetracycline resistance gene tet (X14) and its co-occurrence with tet (X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris [PDF]
Emerging Microbes and Infections, 2020 Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new resistance mechanism of tigecycline.
Yingying Cheng +11 more
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