Results 41 to 50 of about 19,418 (180)

The Plasmid-Borne tet(A) Gene Is an Important Factor Causing Tigecycline Resistance in ST11 Carbapenem-Resistant Klebsiella pneumoniae Under Selective Pressure

Frontiers in Microbiology, 2021
The emergence and prevalence of tigecycline-resistant Klebsiella pneumoniae have seriously compromised the effectiveness of antimicrobial agents in the treatment of infections.
Juan Xu, Zhongliang Zhu, Yanmin Chen, Weizhong Wang, Fang He   +4 more
openalex   +3 more sources

Comment on: High tigecycline resistance in multidrug-resistant Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2007
1. Seaman PF, Ochs D, Day MJ. Comment on: Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: a novel mode of evasion of susceptibility to antiseptics. J Antimicrob Chemother 2007; doi:10.1093/jac/dkm118. 2. Bayston R, Ashraf W, Smith T.
Visanu, Thamlikitkul, Surapee, Tiengrim, Chanwit, Tribuddharat   +2 more
openaire   +2 more sources

Evolution of tet(A) variant mediating tigecycline resistance in KPC-2-producing Klebsiella pneumoniae during tigecycline treatment

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This study investigated the underlying mechanism of the evolution of tigecycline resistance during treatment in a patient infected with Klebsiella pneumoniae harbouring blaKPC-2. Methods: A total of seven clonal K.
Wenli Liao, Lingbo Wang, Xiangkuo Zheng, Ying Zhang, Tao Chen, Cui Zhou, Ye Xu, Lijiang Chen, Tieli Zhou   +8 more
doaj   +1 more source

Effect of ramR loss-of-function insertion on tigecycline resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
Objectives: Tigecycline is an antibacterial agent restricted for use against carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to identify the tigecycline resistance mechanism in clinical CRKP isolates obtained from a 60-year-old ...
Yihan Mao, Qiucheng Shi, Ping Zhang, Yan Jiang, Yunsong Yu   +4 more
doaj   +1 more source

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

mSystems, 2021
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun   +13 more
doaj   +1 more source

Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Under the Pressure of Tigecycline

Frontiers in Microbiology, 2021
Colistin and tigecycline are the last options against carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Intersecting resistance determinants have been detected between these antibiotics; however, there is only limited evidence of such ...
Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, Hui Wang   +7 more
doaj   +1 more source

1456. Resistance Mechanisms of Tigecycline in Enterococcus faecalis [PDF]

Open Forum Infectious Diseases, 2020
Abstract Background Enterococcus faecalis have been regarded as one of the leading causes of the nosocomial infections worldwide. Tigecycline (TGC) is considered as a choice of last resort for the treatment of infections caused by multidrug-resistant E.
Bai, Bing, Wen, Zewen, Lin, Zhiwei, H, Tam Vincent, Yu, Zhijian   +4 more
openaire   +1 more source

Identification of Novel tet(X3) Variants Resistant To Tigecycline in Acinetobacter Species

Microbiology Spectrum, 2022
The emergence of the tet(X) gene is a severe challenge to global public health security, as clinical tigecycline resistance shows a rapidly rising trend. In this research, we identified two tigecycline-resistant Acinetobacter sp. strains containing seven
Yumeng Cheng, Yakun Li, Runhao Yu, Mingxiang Ma, Meng Yang, Hongbin Si   +5 more
doaj   +1 more source

Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Journal of Biomedical Science, 2023
Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS).
Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
doaj   +1 more source

Tigecycline Susceptibility in Multidrug Resistant Acinetobacter Isolates from Turkey

Polish Journal of Microbiology, 2013
The present study aimed to evaluate antimicrobial activity of tigecydcline against 84 multidrug resistant (MDR) Acinetobacter spp. strains by disc diffusion and E-test methods. The results of disc diffusion test were compared according to two different interpretation ways.
Taşli H., Yilmaz F.F., Gül-Yurtsever S., Büyük A., Hoşgör-Limoncu M.   +4 more
openaire   +5 more sources