Results 61 to 70 of about 19,418 (180)

Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Of 26 tigecycline-nonsusceptible Klebsiella pneumonia e (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR ).
Zi-Ke, Sheng, Fupin, Hu, Weixia, Wang, Qinglan, Guo, Zhijun, Chen, Xiaogang, Xu, Demei, Zhu, Minggui, Wang   +7 more
openaire   +2 more sources

Molecular epidemiology and mechanisms of tigecycline resistance in carbapenem‐resistant Klebsiella pneumoniae isolates [PDF]

Journal of Clinical Laboratory Analysis, 2020
AbstractBackgroundThe emergence and transmission of tigecycline‐ and carbapenem‐resistant Klebsiella pneumoniae (TCRKP) have become a major concern to public health globally. Here, we investigated the molecular epidemiology and mechanisms of tigecycline resistance in carbapenem‐resistant K pneumoniae (CRKP) isolates.MethodsForty‐five non‐duplicate CRKP
Yumi Park, Qute Choi, Gye Cheol Kwon, Sun Hoe Koo   +3 more
openaire   +2 more sources

Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.

Microbiology Spectrum, 2021
Tigecycline is regarded as one of the few important last-resort antibiotics to treat complicated skin and intra-abdominal infections. Members of the genus Staphylococcus are zoonotic pathogens and pose a serious threat to public health.
Nannan Wang, Dexi Li, Stefan Schwarz, Shangshang Qin, Hong Yao, Xiang-Dang Du   +5 more
doaj   +1 more source

Efficacy and Safety of Quadruple Therapy With Semisynthetic Tetracycline for Helicobacter pylori Eradication: A Meta‐Analysis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background High antibiotic resistance and limited tetracycline accessibility severely restrict the clinical application of classic bismuth quadruple therapy (BQT), creating an urgent demand for alternative regimens. Methods A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science up to June 3, 2025, for trials ...
Qi‐Qi Guo, Ju Zhang, Xiao‐Jing Zhu, Wei‐Yue Li, Dan‐Yang Zhao, Meng‐Qi Liang, Rong Yan, Yong‐Quan Shi   +7 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Emergence of the resistance‐nodulation‐division efflux pump tmexCD3‐toprJ3 gene confers resistance to tigecycline in Pseudomonas juntendi and Proteus terrae isolated from a pig farm in China [PDF]

, 2022
Jie Yang, Ziyue Zeng, Jufang Hu, Zhihong Liu, Jinrong Gu, Xiaojun Chen, Zhi-Liang Sun, Jiyun Li   +7 more
openalex   +1 more source

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens

Cell Reports
Summary: Tigecycline is a last-resort antibiotic primarily used to treat severe infections caused by multidrug-resistant (MDR) bacteria. However, the emergence of constantly appearing resistance determinants has drastically compromised its clinical ...
Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
doaj   +1 more source

Study on MICs of Tigecycline in Clinical Isolates of Carbapenem Resistant Enterobacteriaceae (CRE) at a Tertiary Care Centre in North India [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Members of family Enterobacteriaceae are the most common Gram-negative bacteria isolated from clinical samples. Those Enterobacteriaceae which have acquired resistance to all β-lactams antibiotics including the carbapenems are ...
Vineeta Khare, Prashant Gupta, Fareya Haider, Rehana Begum   +3 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2008
Sir, Acinetobacter baumannii has emerged as a leading nosocomial pathogen, particularly in intensive care units (ICUs), where several outbreaks have been described. Treatment of severe A. baumannii infection represents a difficult clinical challenge due to the propensity of this organism to acquire antimicrobial resistance, resulting in the emergence ...
A. CAPONE, S. DAREZZO, P. VISCA, N. PETROSILLO, SANTINI, Claudio   +4 more
openaire   +4 more sources