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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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Tight Junctions and Tissue Barriers
Antioxidants & Redox Signaling, 2011The integrity and function of many vertebrate organs depend on cellular barriers that are mainly formed by intercellular protein complexes of the plasma membrane. These cell-cell contacts, tight junctions (TJs), exhibit the most apical localization in the lateral membrane; they regulate the permeability of the paracellular space between opposing ...
Ingolf E, Blasig, Reiner F, Haseloff
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Tight junctions and human diseases
Medical Electron Microscopy, 2003Tight junctions are intercellular junctions adjacent to the apical end of the lateral membrane surface. They have two functions, the barrier (or gate) function and the fence function. The barrier function of tight junctions regulates the passage of ions, water, and various macromolecules, even of cancer cells, through paracellular spaces.
Norimasa, Sawada +6 more
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2006
Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
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Transport across epithelia occurs through both transcellular and paracellular pathways. Transcellular movement of solutes and ions through transporters and channels is energy-dependent, directional, highly selective and regulated. Paracellular transport occurs through tight junctions, which behave like charge- and size-selective channels, but with a ...
James Melvin Anderson +1 more
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Human airway epithelial tight junctions
Microscopy Research and Technique, 1997The flux of fluid, ions, macromolecules, and inflammatory cells across airway epithelium depends in part upon the integrity of its apico-lateral tight junctions. Without the correct balance of fluid and ions, the normal functioning of mucociliary clearance and the neural responsiveness of the airways cannot take place.
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Paracellular permeability and tight junction regulation in gut health and disease
Nature Reviews Gastroenterology and Hepatology, 2023Arie Horowitz +2 more
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