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American Review of Respiratory Disease, 1988
Epithelial cells differentiate by polarizing into an apical and a basolateral domain and by forming tight junctions (TJ) that control permeation through the paracellular route. The molecular nature of this structure, as well as the processes of assembly, sealing, and regulation, are not yet fully understood.
M, Cereijido +2 more
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Epithelial cells differentiate by polarizing into an apical and a basolateral domain and by forming tight junctions (TJ) that control permeation through the paracellular route. The molecular nature of this structure, as well as the processes of assembly, sealing, and regulation, are not yet fully understood.
M, Cereijido +2 more
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Annals of the New York Academy of Sciences, 2009
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
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Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
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Tight junctions and tight junction proteins in mammalian epidermis
European Journal of Pharmaceutics and Biopharmaceutics, 2009Tight junctions (TJ) are barrier forming cell-cell junctions that are found in a variety of cell types and tissues but their existence in mammalian epidermis has been shown only in the last years. A variety of TJ proteins were identified in mammalian epidermis, comprising several members of the claudin family, occludin, and JAM-A as well as ZO-1 and ...
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Cell, 1982
We have analyzed previous thin-section and freeze-fracture observations of the tight junction. We propose that the tight-junction strands represent intramembranous, cylindrical, inverted micelles. At the junctional site, the exoplasmic halves of the plasma membranes are fused into a continuous leaflet.
P, Pinto da Silva, B, Kachar
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We have analyzed previous thin-section and freeze-fracture observations of the tight junction. We propose that the tight-junction strands represent intramembranous, cylindrical, inverted micelles. At the junctional site, the exoplasmic halves of the plasma membranes are fused into a continuous leaflet.
P, Pinto da Silva, B, Kachar
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Tight junctions of oligodendrocytes
Cell and Tissue Research, 1977Freeze-fracture replicas of the rat corpus callosum revealed prominent junctional strands in fractured cell membranes of the somata of oligodendrocytes. The junctional strands were characterized by an elaborate system of straight or slightly undulating rows of linear aggregates of particles or ridges in the P face and furrows in the E face.
E, Tani, T, Itagaki, M, Nakano
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Tight junctions in skin inflammation
Pflügers Archiv - European Journal of Physiology, 2016Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both.
Katja, Bäsler, Johanna M, Brandner
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Journal of Dermatological Science, 2003
Tight junctions (=zonulae occludentes, TJs) function as an effective barrier in simple epithelia. Recent developments in the molecular biology of TJs revealed that TJs also exist in the stratum granulosum and contribute to barrier function in epidermis. Furthermore, several TJ-related junctions were identified in epidermis.
Kazumasa, Morita, Yoshiki, Miyachi
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Tight junctions (=zonulae occludentes, TJs) function as an effective barrier in simple epithelia. Recent developments in the molecular biology of TJs revealed that TJs also exist in the stratum granulosum and contribute to barrier function in epidermis. Furthermore, several TJ-related junctions were identified in epidermis.
Kazumasa, Morita, Yoshiki, Miyachi
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Perspectives on tight junction research
Annals of the New York Academy of Sciences, 2012The tight junction connects neighboring epithelial or endothelial cells. As a general function, it seals the paracellular pathway and thus prevents back‐leakage of just transported solutes and water. However, not all tight junctions are merely tight: some tight junction proteins build their own transport pathways by forming channels selective for small
Jörg-Dieter, Schulzke +3 more
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MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS
Annual Review of Physiology, 1998▪ Abstract The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called the apical junction complex. A growing number of tight junction–associated proteins have been identified, but functions are defined for only a few.
L L, Mitic, J M, Anderson
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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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