Results 261 to 270 of about 301,934 (303)
Some of the next articles are maybe not open access.
Tight junctions and tight junction proteins in mammalian epidermis
European Journal of Pharmaceutics and Biopharmaceutics, 2009Tight junctions (TJ) are barrier forming cell-cell junctions that are found in a variety of cell types and tissues but their existence in mammalian epidermis has been shown only in the last years. A variety of TJ proteins were identified in mammalian epidermis, comprising several members of the claudin family, occludin, and JAM-A as well as ZO-1 and ...
openaire +2 more sources
Annals of the New York Academy of Sciences, 2009
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
openaire +1 more source
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
openaire +1 more source
MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS
Annual Review of Physiology, 1998▪ Abstract The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called the apical junction complex. A growing number of tight junction–associated proteins have been identified, but functions are defined for only a few.
L L, Mitic, J M, Anderson
openaire +2 more sources
Multifunctional strands in tight junctions
Nature Reviews Molecular Cell Biology, 2001Tight junctions are one mode of cell-cell adhesion in epithelial and endothelial cellular sheets. They act as a primary barrier to the diffusion of solutes through the intercellular space, create a boundary between the apical and the basolateral plasma membrane domains, and recruit various cytoskeletal as well as signalling molecules at their ...
S, Tsukita, M, Furuse, M, Itoh
openaire +2 more sources
Tight Junctions and Viral Entry
Future Virology, 2010A wide variety of different viruses use tight junction (TJ) proteins in the course of infection and different mechanisms of pathogen–TJ interactions have been described; pathogens may induce the reorganization or degradation of distinct TJ proteins, reorganization of the cell cytoskeleton, activation of host-cell signaling pathways and/or use TJ ...
ZEISEL M.B., TUREK M., BAUMERT T.F.
openaire +1 more source
Tight junctions in skin inflammation
Pflügers Archiv - European Journal of Physiology, 2016Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both.
Katja, Bäsler, Johanna M, Brandner
openaire +2 more sources
Transmembrane proteins of tight junctions
Seminars in Cell & Developmental Biology, 2000Tight junctions from a morphological and functional boundary between the apical and basolateral cell surface domains of epithelia and endothelia, and regulate selective diffusion along the paracellular space. Two types of four-span transmembrane proteins, occludin and claudins, as well as the single-span protein JAM are associated with tight junctions.
Balda MS, Matter K
openaire +3 more sources
Functional analysis of tight junctions
Methods, 2003Epithelial and endothelial cells are joined to each other via a set of intercellular junctions that differ in their morphological appearance, composition, and function. The tight junction or zonula occludens is the intercellular junction that regulates diffusion between cells and therefore allows endothelia and epithelia to form cellular barriers that ...
Karl, Matter, Maria S, Balda
openaire +2 more sources
Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
openaire +1 more source
Perspectives on tight junction research
Annals of the New York Academy of Sciences, 2012The tight junction connects neighboring epithelial or endothelial cells. As a general function, it seals the paracellular pathway and thus prevents back‐leakage of just transported solutes and water. However, not all tight junctions are merely tight: some tight junction proteins build their own transport pathways by forming channels selective for small
Jörg-Dieter, Schulzke +3 more
openaire +2 more sources