Results 21 to 30 of about 299,276 (297)
A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options [PDF]
, 2016 Tight junction and epithelial barrier disruption is a common trait of many gastrointestinal pathologies, including chemotherapy-induced gut toxicity. Currently, there are no validated in vitro models suitable for the study of chemotherapy-induced mucosal
Bowen, J. +5 more
core +1 more source
Structural dynamics of tight junctions modulate the properties of the epithelial barrier.
PLoS ONE, 2019 Tight junctions are dynamic structures that are crucial in establishing the diffusion and electrical barrier of epithelial monolayers. Dysfunctions in the tight junctions can impede this barrier function and lead to many pathological conditions ...
Aapo Tervonen +3 more
doaj +1 more source
Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]
PLoS ONE, 2017 SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman +3 more
doaj +1 more source
Molecules, 2023 Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses.
Vishnu Raj +7 more
doaj +1 more source
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]
, 2017 Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo +13 more
core +2 more sources
Ectoplasmic specialization: A friend or a foe of spermatogenesis? [PDF]
, 2006 The ectoplasmic specialization (ES) is a testis-specific, actin-based hybrid anchoring and tight junction. It is confined to the interface between Sertoli cells at the blood-testis barrier, known as the basal ES, as well as between Sertoli cells and ...
Mruk, DD, Lee, WM, Cheng, CY, Yan, HHN
core +5 more sources
Journal of Inflammation Research, 2021 Dong Zhang,1 Jin-tao Zhang,1 Yun Pan,1 Xiao-fei Liu,1 Jia-wei Xu,2 Wen-jing Cui,1 Xin-rui Qiao,1 Liang Dong1,2 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China ...
Zhang D +7 more
doaj
Cells, 2022 Transmembrane proteins of adherens and tight junctions are known targets for viruses and bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of epithelial cells, but it is not clear whether ACE2 is localized at apical
Florian Rouaud +2 more
doaj +1 more source
ZOning out Tight Junctions [PDF]
Cell, 2006 The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal ...
Shin, K, Margolis, B
openaire +3 more sources
BMC Microbiology, 2010 Background Intestinal barrier function is important for preserving health, as a compromised barrier allows antigen entry and can induce inflammatory diseases.
McCann Mark J +6 more
doaj +1 more source