Results 161 to 170 of about 27,271 (263)

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li, Zheyang Zhang, Ming Zhu, Xiaofan Li, Jinxian Dai, Ping Chen, Fei Chen, Xianling Chen, Yiding Yang, Xiaohong Yuan, Ronghan Tang, Zhijuan Zhu, Hongli Lin, Ting Lin, Mengsha Tong, Tao Chen, Yuanzhong Chen, Jialiang Huang, Nainong Li   +18 more
wiley   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

The effect of TIGIT and PD1 expression on T cell function and prognosis in adult patients with acute myeloid leukemia at diagnosis

Cancer Immunology, Immunotherapy
T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) is a recently-identified immune checkpoint molecule, and no study ever explores the prognostic significance of TIGIT on bone marrow T cells of newly-diagnosed acute myeloid leukemia (AML ...
Dai-Hong Xie, Si-Qi Li, Kai Sun, Jun Wang, Zong-Yan Shi, Ya-Zhe Wang, Yan Chang, Xiao-Ying Yuan, Hao Jiang, Qian Jiang, Ying-Jun Chang, Xiao-Jun Huang, Ya-Zhen Qin   +12 more
doaj   +1 more source

Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical highlights Tumour subpopulations with high malignancy show reduced interferon signalling and reduced MHC‐I expression. Tumour‐associated macrophages (TAMs) differentiate into two opposing states: SPP1+ TAMs and CXCL9+ TAMs. Among immune ecotypes, T‐cell‐enriched ecotypes are linked with high MHC‐I expression in tumour cells while desert ...
Lingjuan Huang, Huihui Hou, Xiyuan Zhang, Liang Dong, Wensheng Shi, Mason Liu, Jie Sun, Anil Prakash, Haoqiu Song, Shiyao Pei, Xin Li, Xiang Chen, Shenglin Mei, Mingzhu Yin   +13 more
wiley   +1 more source

Metabolic Reprogramming of the Pre‐Metastatic Niche: A Sweet Spot for Anti‐Tumor Immunity

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Xuan Zhang, Xinghua Long
wiley   +1 more source

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals [PDF]

, 2017
Betts, Michael R., Buggert, Marcus, Deeks, Steven G., Frederiksen, Juliet, Hecht, Frederick Mm, Karlsson, Annika C., Ljunggren, Hans-Gustaf, Lund, Ole, Naji, Ali, Reyes-Terán, Gustavo, Scharf, Lydia, Sönnerborg, Anders, Tauriainen, Johanna   +12 more
core   +1 more source

Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33

European Journal of Immunology, Volume 56, Issue 2, February 2026.
GPA33 identifies stable human regulatory T cells suitable for therapeutic use. GPA33+ Treg subsets expand efficiently, maintain high FOXP3+Helios+ expression, and lack production of IL‐2, IFNγ, and IL‐17A. GPA33, alone or combined with TIGIT, also enables robust post‐expansion isolation of pure, stable Treg cells for adoptive cell therapy.
Florencia Morgana, Edith Slot, Derk Amsen   +2 more
wiley   +1 more source

Epstein‐Barr Virus Infection at Single‐Cell Resolution

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Epstein‐Barr virus (EBV) infection has been studied at single‐cell resolution for six decades and counting. Such investigations can reveal virus‐host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time.
Elliott D. SoRelle
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source