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A Systematic Review and Meta-Analysis on the Significance of TIGIT in Solid Cancers: Dual TIGIT/PD-1 Blockade to Overcome Immune-Resistance in Solid Cancers

International Journal of Molecular Sciences, 2021
Preclinical studies have indicated that T-cell immunoglobulin and ITIM domain (TIGIT) can substantially attenuate anti-tumoral immune responses. Although multiple clinical studies have evaluated the significance of TIGIT in patients with solid cancers ...
Seyedeh Momeneh Mohammadi, Parisa Lotfinejad, Nicola Silvestris   +2 more
exaly   +2 more sources

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

Cancer Cell, 2021
Tyler Jacks, Toni Delorey, Prajan Divakar   +2 more
exaly  

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

Immunity, 2022
Xiaozheng Xu, Enfu Hui, Eric J Bennett
exaly  

Anti-TIGIT therapies for solid tumors: a systematic review

ESMO Open, 2023
Adrien Rousseau, C Parisi
exaly  

TIGIT promotes CD8+T cells exhaustion and predicts poor prognosis of colorectal cancer

Cancer Immunology, Immunotherapy, 2021
Hongbo Wei, Bo Wei, Jianpei Liu
exaly  

The -linked glycosylations of TIGIT Asn and Asn facilitate PVR/TIGIT interaction

Biochemical and Biophysical Research Communications, 2021
Jye-Lin Hsu, Jung-Mao Hsu, Mien-Chie Hung   +2 more
exaly  

TIGIT presents earlier expression dynamic than PD-1 in activated CD8 T cells and is upregulated in non-small cell lung cancer patients

Experimental Cell Research, 2020
Chong Bai
exaly  

Simultaneous blockade of TIGIT and HIF-1α induces synergistic anti-tumor effect and decreases the growth and development of cancer cells

International Immunopharmacology, 2021
Mehrdad Fathi, Hamed Mohammadi, Ali Jalili   +2 more
exaly  

Combined evaluation of the expression status of CD155 and TIGIT plays an important role in the prognosis of LUAD (lung adenocarcinoma)

International Immunopharmacology, 2020
Ji Cui, Yiyan Lei, Zunfu Ke
exaly