ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We evaluated whether GPMs can also alter the capacity of annulus
K. Stradovnik‐Poikilidis +8 more
wiley +1 more source
Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes. [PDF]
Chaffin Z +7 more
europepmc +1 more source
Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait +5 more
wiley +1 more source
Machine-Learning Approach to Identify Tissue Inhibitors of Metalloproteinases (TIMP) and Clinical Variables Predicting Executive Phenotypes in HIV-infected Adults. [PDF]
Weng YW +4 more
europepmc +1 more source
Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma +5 more
wiley +1 more source
From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart. [PDF]
Kendall AN, Palmer IMA, Collins HE.
europepmc +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Serum TIMP-1 concentrations are associated with cancer incidence and cancer-related mortality in a population-based cohort. [PDF]
Nieminen MT +10 more
europepmc +1 more source
ABSTRACT Obesity is closely associated with metabolic dysfunction, leading to impaired glucose and lipid homeostasis and contributing to the development of metabolic dysfunction–associated liver disease (MASLD). Propolis is a bee‐derived natural product rich in bioactive compounds and widely recognized for its antioxidant, anti‐inflammatory, and ...
Caroline Alves de Araújo +12 more
wiley +1 more source
POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review). [PDF]
Wu H, Dong X.
europepmc +1 more source

