Results 171 to 180 of about 30,124 (283)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes. [PDF]

BMJ Open Diabetes Res Care
Chaffin Z, Ghetti S, Tancredi D, Rewers A, Rewers M, Gilles S, Ander B, Glaser N.   +7 more
europepmc   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, Volume 38, Issue 27, 14 May 2026.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Quantification and Correlation of Salivary Tissue Inhibitor Matrix Metalloproteinases 1 and 2 Levels in Caries-free and Caries-active Children: A Randomized Clinical Trial. [PDF]

Int J Clin Pediatr Dent
Thimmegowda U, Sampreetha G.
europepmc   +1 more source

Neuroprotective Properties of Litchi chinensis and Its Phytochemicals in Preclinical Models of Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Purpose Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving amyloid‐β deposition, tau hyperphosphorylation, oxidative stress, and neuroinflammation. This review systematically evaluates the neuroprotective effects of Litchi chinensis and its phytochemicals against AD, focusing on modulation of Aβ accumulation, tau ...
Emon Mia, Md. Arif Hossain, Asmaul Husna Bristy, Rakib Hossan, Uzma Asif, Asif Khan Sherwani, Mohammad Y. Alshahrani, Samy Selim, Imam Hossen Rakib, Noshin Tasnim Yana, Khadija Akter, Md. Sakib Al Hasan   +11 more
wiley   +1 more source

Advances in Extracellular Matrix Metalloproteinases: Implications for Renal Cell Carcinoma Pathophysiology, Diagnostics, and Therapeutics. [PDF]

Medicines (Basel)
Krikou E, Anastasiou IA, Sarantis P, Gakiopoulou H, Theochari I, Grigoriadou D, Lazaris AC, Lakiotaki E.   +7 more
europepmc   +1 more source

Diagnostic and Therapeutic Roles of Extracellular Vesicles in Chronic Kidney Disease: A Systematic Review

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
This systematic review compiles and analyses 364 studies on chronic kidney disease (CKD) that investigated extracellular vesicles (EVs) for diagnostic and therapeutic applications. By systematically categorizing data according to EV source and cargo, it provides an integrated overview of EV application for CKD, highlighting common approaches and shared
Tunahan Ergunay, Alessia Brossa, Benedetta Bussolati   +2 more
wiley   +1 more source

MMPs at Work: Deciphering Their Role in the Cellular Mechanisms of Orthodontic Tooth Movement. [PDF]

Int J Mol Sci
Patrão MR, Pereira PM, Caldeira J, Salema-Oom M.   +3 more
europepmc   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Morphometry and Immunoexpression of Metalloproteinase 2 and Its Inhibitor in the Fibrotic and Non-Fibrotic Grafted Kidney-Digital Analysis. [PDF]

Biomedicines
Szypulska-Koziarska D, Kwiatkowska E, Opara-Bajerowicz M, Wilk A.   +3 more
europepmc   +1 more source