Results 161 to 170 of about 16,067 (252)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

Cellular senescence in Crohn's disease: a double-edged sword in intestinal fibrosis. [PDF]

Front Immunol
Liu J, Yu L.
europepmc   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, Volume 183, Issue 18, Page 5423-5439, September 2026.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

Advances in Extracellular Matrix Metalloproteinases: Implications for Renal Cell Carcinoma Pathophysiology, Diagnostics, and Therapeutics. [PDF]

Medicines (Basel)
Krikou E, Anastasiou IA, Sarantis P, Gakiopoulou H, Theochari I, Grigoriadou D, Lazaris AC, Lakiotaki E.   +7 more
europepmc   +1 more source

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8157-8171, September 2026.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities. [PDF]

Front Immunol
Wu M, Han Z, Wei W, Niu Y, Wang H, Meng F, Wu Q.   +6 more
europepmc   +1 more source

Diabetic Corneal Neuropathy as a Window Into Diabetic Foot Risk: A Large‐Scale Association Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8219-8229, September 2026.
ABSTRACT Aims To evaluate the association between diabetic corneal neuropathy and diabetic foot risk by examining corneal nerve features, clinical characteristics, and tear mediators in patients with different diabetic foot risk categories. Methods In this cross‐sectional study, 710 participants underwent diabetic foot examination, in vivo confocal ...
Chang Liu, Mingyi Yu, Isabelle Xin Yu Lee, Gavin Patrick O'Donnell, Hong Chang Tan, Aya Takahashi‐Nakajima, Yixin Wang, Mui Hui Koh, Ho Sean Matthew Chung‐Hei, Hasika Wickrama Senevirathne, Hla Myint Htoon, Ching‐Yu Cheng, Yu‐Chi Liu   +12 more
wiley   +1 more source

Matrix Metalloproteinases and Cardiac Remodelling in Smokers with Acute Coronary Syndrome. [PDF]

Int J Mol Sci
Aminuddin A, Samah N, Nor FM, Wan Razali WMH, Cong BB, Mohamad SF, Hamid AA, Norhisham WK, Ugusman A.   +8 more
europepmc   +1 more source

Carbocisteine Reduces Airway Mucus Obstruction and Alters Inflammatory Cell Populations in a Model of Muco‐Obstructive Lung Disease

Immunology &Cell Biology, Volume 104, Issue 8, Page 833-844, September 2026.
Mice with a muco‐obstructive lung disease phenotype were treated with the mucoactive drug, carbocisteine, which resulted in reduced airway mucus and an alteration in the lung mononuclear cell population which was either as a direct effect of, or secondary to, improved mucus clearance.
Peter Ferris, Ryan Brown, Michael McKelvey, Daniel F. McAuley, Marcus A. Mall, Bronwen Connolly, Clifford C. Taggart   +6 more
wiley   +1 more source

MMPs at Work: Deciphering Their Role in the Cellular Mechanisms of Orthodontic Tooth Movement. [PDF]

Int J Mol Sci
Patrão MR, Pereira PM, Caldeira J, Salema-Oom M.   +3 more
europepmc   +1 more source