Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation [PDF]
Redox Biology, 2023 Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TFPI ...
Janina Wittig +8 more
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MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium [PDF]
Scientific Reports, 2022 A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin modification ...
Veerle Kremer +8 more
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch +7 more
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Associations of tissue factor and tissue factor pathway inhibitor with organ dysfunctions in septic shock [PDF]
Scientific ReportsCoagulopathy, microvascular alterations and concomitant organ dysfunctions are hallmarks of sepsis. Attempts to attenuate coagulation activation with an inhibitor of tissue factor (TF), i.e.
Georg Franz Lehner +9 more
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Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia [PDF]
Scientific Reports, 2021 The infiltration of chronic lymphocytic leukemia (CLL) cells into lymphoid organs correlates with disease severity. CXCL12 is a key chemotactic factor for the trafficking of CLL.
Xue Yan Cui +11 more
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Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma [PDF]
Scientific ReportsRenal and ovarian clear cell carcinoma (CCC) are both characterized by a clear cytoplasm and exhibit similar genomic alterations and clinical characteristics. We hypothesized that both CCCs may share clinical biomarker. Tissue factor pathway inhibitor 2 (
Hiroki Ito +12 more
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Tissue factor pathway inhibitor 2 as a serum biomarker for endometrial cancer: a single-center retrospective study [PDF]
BMC CancerBackground Endometrial cancer is the most common gynecological malignancy; however, there is no useful blood diagnostic biomarker. This study aimed to determine the utility of tissue factor pathway inhibitor 2 (TFPI2), a biomarker of ovarian cancer, as a
Mari Uomoto +12 more
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Biomedicines, 2023 Background: Preeclampsia is a hypertensive disorder of pregnancy that causes maternal and perinatal morbidity and mortality worldwide. Preeclampsia is associated with complex abnormalities of the coagulation and fibrinolytic system. Tissue factor (TF) is
Hiroshi Kobayashi +4 more
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Tissue factor pathway inhibitor for prediction of placenta-mediated adverse pregnancy outcomes in high-risk women: AngioPred study. [PDF]
PLoS ONE, 2017 OBJECTIVE:The study aimed to evaluate if the rate of tissue factor pathway inhibitor during pregnancy and following delivery could be a predictive factor for placenta-mediated adverse pregnancy outcomes in high-risk women.
Aurélie Di Bartolomeo +6 more
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Tissue factor and tissue factor pathway inhibitor [PDF]
Anaesthesia, 2004 Summary The classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways.
G C, Price, S A, Thompson, P C A, Kam
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