Results 61 to 70 of about 89,951 (308)

Predictive Markers for Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis C Virus Genotype4a

Middle East Journal of Cancer, 2018
Background: Egypt has the highest prevalence of hepatitis C virus worldwide. Monitoring hepatitis C-infected patients for hepatocellular carcinoma development is an important clinical issue to diagnose these patients during the potentially curable ...
Ebtsam R. Zaher, Abeer A. Ghazal, Wael A. Ellabban, Mona El-Deeb, Lamyaa Al-Ghaleed   +4 more
doaj  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Matrix metalloproteinase-2, -9, and tissue inhibitor of MMP-2 gene polymorphisms in Taiwanese periodontitis patients

Journal of Dental Sciences, 2016
Background/purpose: Matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs (TIMPs) have been shown to play an important role in the pathogenesis of tissue destruction in periodontitis. The associations between single nucleotide polymorphisms (SNPs)
Yu-Feng Hsiao, Li-Chiu Yang, Yu-Shian Chou, Ya-Ping Ho, Ying-Chu Lin, Kun-Yen Ho, Yi-Min Wu, Chi-Cheng Tsai   +7 more
doaj   +1 more source

Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma [PDF]

International Journal of Cancer, 2001
Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential for cell-mediated activation of MMP-
T, Yoshizaki, Y, Maruyama, H, Sato, M, Furukawa   +3 more
openaire   +2 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Plasma matrix metalloproteinases in neonates having surgery for congenital heart disease

Heart International, 2009
During cardiopulmonary-bypass matrix-metalloproteinases released may contribute to ventricular dysfunction. This study was to determine plasma matrix-metalloproteinases in neonates after cardiopulmonary-bypass and their relation to post-operative course.
David B. Ross, Richard Schulz, Po-Yin Cheung, Ivan M. Rebeyka, Rhonda J. Rosychuk, John Dyck, Ari R. Joffe, Christina Schulz   +7 more
doaj   +1 more source

DYNAMIC ALTERATIONS OF CONNEXIN 43, MATRIX METALLOPROTEINASE-2 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-2 DURING VENTRICULAR FIBRILLATION IN DOGS [PDF]

Heart, 2012
Objectives We aimed to investigate the dynamic alterations of cardiac connexin 43 (Cx 43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the setting of different ventricular fibrillation (VF) duration and try to reveal the possible initiation and/or persistence mechanisms
Wang Jing, Li Jingsha, Liu Hongzhen, Zeng Qixian, Liu Donglin, Meng Xianglin, Zhang Yun, Zhong Jingquan   +7 more
openaire   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V.   +27 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos

, 2001
Embryo implantation in humans and rodents is a highly invasive yet tightly controlled process involving extracellular matrix (ECM) degradation. Matrix metalloproteinase 9 (MMP-9) has been implicated as the major facilitator of this ECM degradation. MMP-9
Whiteside, Eliza J., Harvey, Mark, Herington, Adrian C., Herington, Adrian, Jackson, Michael M., Edwards, Dylan, Jackson, Michael, Whiteside, Eliza, Harvey, Mark B., Edwards, Dylan R.   +9 more
core   +1 more source