Results 11 to 20 of about 174,270,932 (291)
Inactivation of tissue inhibitor of metalloproteinase‐1 by peroxynitrite [PDF]
FEBS Letters, 1996 Peroxynitrate (ONOO−) has recently been implicated in connective tissue destruction in vivo. We have studied the effect of ONOO− on the activity of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in vitro. The inactivation of TIMP‐1 by ONOO− was dose dependent with 50 μM ONOO− reducing the inhibitory activity of TIMP‐1 towards gelatinase‐A by 50 ...
Frears, Emma R. +4 more
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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer
World Journal of Gastroenterology, 2011 To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined ...
Yılmaz, Özkan +11 more
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Bioengineering, 2022 Hypertension (HTN) is a leading risk factor for cardiovascular (CV) disease. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be actively involved in the remodeling of the CV extracellular matrix (ECM) during ...
Krasimir Kostov, Alexander Blazhev
doaj +3 more sources
Saudi Dental Journal, 2014 Background: Matrix metalloproteinase-1 (MMP-1) is a member of a family of enzymes that can degrade most extracellular matrix macromolecules. Extracellularly, MMPs are controlled by tissue inhibitors of metalloproteinases (TIMPs) and by mechanisms of pro ...
Pallavi S. Ghodpage +3 more
doaj +3 more sources
Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer [PDF]
International Journal of Breast Cancer, 2012 Introduction. Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both pro-
Arunee Dechaphunkul +6 more
doaj +3 more sources
Roles of Tissue Inhibitor of Metalloproteinase-1 in Severe Asthma. [PDF]
Allergy Asthma Immunol Res, 2023 Kim SH.
europepmc +3 more sources
Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy. [PDF]
Am J Trop Med Hyg, 2021 ABSTRACT. Chagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and ...
Garcia KO +17 more
europepmc +4 more sources
Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases
Brain Research BulletinCentral nervous system (CNS) diseases are characterized by high morbidity, long disease courses, and irreversible neurological impairment, often resulting from damage to the neurovascular unit (NVU).
Linke Zhong +6 more
doaj +3 more sources
Modulation of plasma matrix metalloproteinase 9 and its inhibitors by vitamin D. [PDF]
, 2012 PhDMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are upregulated in a variety of diseases. Hypothesis: As TIMP-1 levels are elevated in liver fibrosis, might a similar process occur in essential hypertension driven left ...
Timms, Peter McLean
core +4 more sources
Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection [PDF]
Infection and Immunity, 2005 ABSTRACT Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates.
Marie Mei, Lee +7 more
openaire +2 more sources