Results 141 to 150 of about 200,456,440 (293)

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

Folia Histochemica et Cytobiologica, 2010
The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2)and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathologicalfeatures of ...
Magdalena Groblewska, Barbara Mroczko, Mariusz Gryko, Boguslaw Kędra, Maciej Szmitkowski   +4 more
doaj  

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Tumor necrosis factor α, protein gene product 9.5, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 presence in congenital intra-abdominal adhesions in children under one year of age. [PDF]

Arch Med Sci, 2021
Junga A, Pilmane M, Ābola Z, Volrāts O.   +3 more
europepmc   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Utility of Tissue Inhibitor Metalloproteinase-1 and Osteopontin as Prospective Biomarkers of Early Cardiovascular Complications in Type 2 Diabetes

, 2018
AIM: This work investigated associations between tissue inhibitor metalloproteinase-1 and diabetic cardiovascular diseases in type 2 diabetic patients; also it investigated the role of osteopontin in the diagnosis of type 2 cardiovascular diabetes ...
Ahmed Ibrahim Amin, Ahmed Osman Egiza, Doaa Samir Salah El-Din   +2 more
core   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

EFEK APLIKASI INTERPROKSIMAL SEPARATOR ELASTIS ORTODONTI TERHADAP KADAR MATRIK METALLOPROTEINASE 8 (MMP-8) dan TISSUE INHIBITOR MATRIK METALLOPROTEINASE 1 (TIMP-1) (Penelitian Eksperimental Laboratoris pada Tikus Sprague Dawley) [PDF]

, 2018
Aplikasi interproksimal separator elastis orthodonti berbahan elastomer pada perawatan orthodontik menghasilkan perubahan biokimiawi pada jaringan periodontal.
Abdurrohman, Muhamat Muhtar Safangat
core  

Effects of Electroacupuncture Stimulation of “Jiaji”(EX-B 2) on Expression of Matrix Metalloproteinase-13 and Tissue Inhibitor of Metalloproteinase-1 in Intervertebral Disc Tissue in Rabbits with Lumbar Intervertebral Disc Degeneration

针刺研究, 2014
Objective To observe the effect of electroacupuncture(EA)stimulation of"Jiaji"(EX-B 2)on the expression of matrix metalloproteinase-13(MMP-13)and tissue inhibitor of metalloproteinase-1(TIMP-1)proteins in the lumbar disc in rabbits with lumbar ...
ZOU Jing, HUANG Guo-fu, ZHANG Qi, GAO Yu, WANG Bo-yi   +4 more
doaj   +2 more sources

Maternal Plasma Levels of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 as Predictive Biomarkers of Preeclampsia

Clinical and Experimental Obstetrics & Gynecology
Background: Preeclampsia (PE), a severe pregnancy complication, is a major contributor to maternal and perinatal morbidity and mortality worldwide.
Thuy Thanh Nguyen, Ngoc Anh Le, Do Tung Dac, Thi Ngoc Dung Ngo, Son Hai Doan, Thi Ngoc Thao Nguyen   +5 more
doaj   +1 more source