Results 201 to 210 of about 62,716 (254)

Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human subconjunctival tissues

Current Eye Research, 1998
To evaluate the roles of fibroblast proteins in the remodeling of the subconjunctival connective tissue, we immunohistochemically assessed the expression of matrix metalloproteinases (MMP)-1 and -2, and the tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2 in cultured human subconjunctival fibroblasts and in normal and healing human ...
Yoshitaka Ohnishi, Osamu Yamanaka, O Yamanaka   +2 more
exaly   +3 more sources

Metalloproteinases and tissue inhibitors of metalloproteinases

Breast Cancer Research and Treatment, 1998
Because the proteolytic degradation of extracellular matrix is required for invasion and metastasis, it would appear that the important family of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) might be prognostic indicators of the invasive potential of a breast tumor.
M, Toi, S, Ishigaki, T, Tominaga
openaire   +2 more sources

Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

Journal of Autoimmunity, 1999
Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes. MMPs are capable of disrupting the blood-brain barrier (BBB), mediating the destruction of extracellular matrix and myelin components. MMPs are also involved in the processing of a variety of cell surface molecules, including the proinflammatory cytokine TNF-alpha. Each of these
Ozenci, V, Rinaldi, L, Teleshova, N, Matusevicius, D, Kivisäkk, P, Kouwenhoven, M, Link, H   +6 more
openaire   +4 more sources

Structural Basis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Molecular Biotechnology, 2003
The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all of which exhibit a catalytic domain of a common metzincin-like topology, and which are involved in degradation of the extracellular matrix but also in a number of other biologic processes. Normally, the proteolytic activity of
Maskos, K., Bode, W.
openaire   +3 more sources

Structural Basis of the Matrix Metalloproteinases and Their Physiological Inhibitors, the Tissue Inhibitors of Metalloproteinases

Biological Chemistry, 2003
The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
openaire   +3 more sources

Characterization of Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Plasma

Connective Tissue Research, 1992
In this study, we have identified and characterized metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) in human plasma. Treatment of plasma with trypsin or aminophenylmercuric acetate resulted in activation of latent gelatinolytic activity.
D, Moutsiakis, P, Mancuso, H, Krutzsch, W, Stetler-Stevenson, S, Zucker   +4 more
openaire   +2 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function

Reviews of Reproduction, 1998
Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the ...
E W, McIntush, M F, Smith
openaire   +2 more sources

Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis

Current Opinion in Lipidology, 1998
The ability of the metalloproteinases to degrade extracellular matrix proteins is essential for the matrix remodelling that occurs during infiltration of inflammatory cells, intimal thickening, angiogenesis and plaque rupture which are a result of atherosclerosis.
openaire   +2 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas

Journal of Neurosurgery, 1995
✓ The gene expression of five matrix metalloproteinases (MMPs) and two tissue inhibitors of metalloproteinases (TIMPs) was studied in human gliomasin vivoandin vitroto evaluate their roles in glioma invasion. Simultaneous expression of one to four MMP genes and two TIMP genes was found in 17 surgical glioma specimens, and one MMP (gelatinase A) gene ...
A, Nakano, E, Tani, K, Miyazaki, Y, Yamamoto, J, Furuyama   +4 more
openaire   +2 more sources