Results 271 to 280 of about 105,810 (308)

Quantification of matrix metalloproteinases and tissue inhibitors of metalloproteinase in prostatic tissue: Analytical aspects

The Prostate, 1998
The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung, M, Lein, N, Ulbrich, B, Rudolph, W, Henke, D, Schnorr, S A, Loening   +6 more
openaire   +2 more sources

Matrix metalloproteinases and their tissue inhibitors in endocrinology

Trends in Endocrinology & Metabolism, 1996
Matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs) have been widely implicated in tissue resorption, degradation, and fibrosis in a range of normal and abnormal processes, but recently defined additional actions suggest much broader and independent roles for different members of these gene families.
openaire   +2 more sources

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma

Journal of Surgical Oncology, 2010
AbstractBackground and ObjectivesMatrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs).
Ming, Zhang, Guan-Yu, Zhu, Hong-Yu, Gao, Shu-Peng, Zhao, Yingwei, Xue   +4 more
openaire   +2 more sources

Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression

Frontiers in Bioscience, 2007
Together, the matrix metalloproteinases (MMPs) are capable of degrading every component of the extracellular matrix (ECM). Besides degradation of the ECM, MMPs release bioactive molecules from the matrix or cell surface and play important role in tissue repair after injury, development and in a number of pathologies including arthritis and cancer ...
Clark IM, Swingler TE, Young DA
openaire   +3 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis

Cardiovascular Pathology, 2006
Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung, Honglin, Luo, Bobby, Yanagawa, Hon Sing, Leong, Dinesh, Samarasekera, John C K, Lai, Agripina, Suarez, Jingchun, Zhang, Bruce M, McManus   +8 more
openaire   +2 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adenocarcinomas

Diseases of the Colon & Rectum, 1996
Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
openaire   +2 more sources

Tissue Inhibitor of Metalloproteinase Expression

1998
Invasion and metastasis are the most life threatening aspects of the oncogenic process. Present therapies, which focus mainly on disruption of growth and division of tumour cells, are of limited use against most highly malignant solid tumours, as they do not combat the invasive and metastatic characteristics of the tumour cells.
A. M. McElligott, A. H. Baker, H. McGlynn   +2 more
openaire   +1 more source

The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer

Surgical Oncology, 1995
Studies suggest that the interplay between matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitor of metalloproteinases (TIMPs) is an important mediator of tumour invasion and metastasis. Using immunohistochemistry, 40 specimens of colorectal cancer were examined for the presence of TIMP-1 and the MMPs, stromelysin, gelatinases A and B
N C, Gallegos, C, Smales, F J, Savage, R M, Hembry, P B, Boulos   +4 more
openaire   +3 more sources

Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

Critical Reviews™ in Eukaryotic Gene Expression, 1997
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
openaire   +2 more sources

Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis

Tuberculosis, 2001
Matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) have been found in high concentrations in pleural effusions. Because MMP and TIMP may play a part in the causation of the fibrosis seen in tuberculous (TB) pleuritis their occurrence was examined.Pleural effusion fluid and plasma concentrations of MMP-1, MMP-2, MMP-3 ...
G, Hoheisel, U, Sack, D S, Hui, K, Huse, K S, Chan, K K, Chan, K, Hartwig, E, Schuster, G H, Scholz, J, Schauer   +9 more
openaire   +2 more sources