Results 61 to 70 of about 17,677,818 (279)

IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection

Nature Communications, 2023
CD8+ T cell tissue resident memory (TRM) cells are especially suited to control pathogen spread at mucosal sites. However, their maintenance in lung is short-lived. TCR-dependent NFkB signaling is crucial for T cell memory but how and when NFkB signaling
Curtis J. Pritzl, Dezzarae Luera, Karin M. Knudson, Michael J. Quaney, Michael J. Calcutt, Mark A. Daniels, Emma Teixeiro   +6 more
doaj   +1 more source

Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies

EMBO Molecular Medicine, 2023
Idiopathic inflammatory myopathies (IIM) are rare autoimmune systemic diseases characterized by muscle weakness and the presence of muscle‐infiltrating T cells.
Alexandra Argyriou, Begum Horuluoglu, Angeles Shunashy Galindo‐Feria, Juan Sebastian Diaz‐Boada, Merel Sijbranda, Antonella Notarnicola, Lara Dani, Annika van Vollenhoven, Daniel Ramsköld, Inger Nennesmo, Maryam Dastmalchi, Ingrid E Lundberg, Lina‐Marcela Diaz‐Gallo, Karine Chemin   +13 more
doaj   +1 more source

Tissue-resident memory T cells: Local guards of the thymus [PDF]

, 2013
T-cell surveillance of nonlymphoid tissues has traditionally been ascribed to recirculating memory T cells that continuously patrol the body. Extending this concept, recent evidence suggests that T cells also exist as nonmigratory memory cells that ...
Mackay, LK, Gebhardt, T
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tissue-resident memory CD8+ T cells and their role in the immune response to infection and vaccination

Инфекция и иммунитет
A variety of body tissues contain tissue-resident memory CD8+ T cells — long-lived multifunctional effector cells formed during the immune response to infection, which populate previously infected tissue long term.
Vladimir Y. Talayev, Olga N. Babaykina, Maria V. Svetlova, Irina Y. Zaichenko, Elena V. Kurkova   +4 more
doaj   +1 more source

A Novel Technique for the Generation of Substantial Numbers of Functional Resident T Cells from Kidney Tissue

Cells, 2022
Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells obtained by the standard method of enzymatic tissue dissociation.
Michiel G. H. Betjes, Frederique Prevoo, Thierry P. P. van den Bosch, Mariska Klepper, Nicolle H. R. Litjens   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8⁺ T cells.

, 2016
Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating
Kastenmüller, Wolfgang, Drexler, I., Hessel, Christian, Tao, Ronny, Korn, Thomas, Gasteiger, Georg, Tao, R., Koenig, Paul-Albert, Busch, D.H., Tao, Sha, Anne Fellenzer, Busch, Dirk H., Heikenwalder, Mathias, Muschaweckh, Andreas, König, P.A, Andreas Muschaweckh, Georg Gasteiger, Paul-Albert König, Wolfgang Kastenmüller, Dirk H. Busch, Fellenzer, Anne, Kastenmüller, G., Ingo Drexler, Heikenwälder, M., Gasteiger, G., Sha Tao, Fellenzer, A., Buchholz, V.R., Thomas Korn, Tao, S., Christian Hessel, Veit R. Buchholz, Mathias Heikenwälder, Ronny Tao, Hessel, C., Korn, T., Muschaweckh, A., Buchholz, Veit R., Drexler, Ingo   +38 more
core   +2 more sources

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

Cell Reports, 2019
Summary: Tissue-resident memory T (Trm) cells are described as having a “sensing and alarming” function, meaning they can rapidly release cytokines in response to local cognate antigen recognition, which in turn, draws circulating immune cells into the ...
Chenghao Ge, Ian R. Monk, Angela Pizzolla, Nancy Wang, James G. Bedford, Timothy P. Stinear, Glen P. Westall, Linda M. Wakim   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source