Results 121 to 130 of about 62,626 (262)
Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness
Frontiers in Physiology, 2014 Titin-based myofilament stiffness is largely modulated by phosphorylation of its elastic I-band regions N2-Bus (decreases passive stiffness, PT) and PEVK (increases PT). Here, we tested the hypothesis that acute exercise changes titin phosphorylation and
Anna Eliane Müller +6 more
doaj +1 more source
Foot protein isoforms are expressed at different times during embryonic chick skeletal muscle development. [PDF]
, 1991 We have investigated the time course of expression of the alpha and beta triad junctional foot proteins in embryonic chick pectoral muscle. The level of [3H]ryanodine binding in muscle homogenates is low until day E20 of embryonic development, then ...
Airey, JA +6 more
core +1 more source
Small Science, Volume 6, Issue 1, January 2026.This study reveals how a multidomain protein can misfold through subtle internal frustrations rather than by swapping entire domains. Using Φ‐value analysis, the authors map the structural features that govern folding and misfolding in the X11 PDZ1–PDZ2 scaffold.
Valeria Pennacchietti +8 more
wiley +1 more source
Disease Models & Mechanisms, 2019 Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been found in about half of HCM patients, while the genetic etiology and pathogenesis remain ...
Yuta Higashikuse +15 more
doaj +1 more source
Journal of Food Science, Volume 91, Issue 1, January 2026.ABSTRACT This study investigated the effects of postmortem aging on the nutritional quality and physicochemical properties of myofibrillar proteins (MFP) in Bactrian camel meat. In this study, hindlimb meat from five Bactrian camels was aged at 4°C and sampled on D0, D1, D3, D5, and D7.
Gai Hang, Liang Ming, Rendalai Si
wiley +1 more source
Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions [PDF]
, 2021 Robert Romano +7 more
openalex +1 more source
APMIS, Volume 134, Issue 1, January 2026.ABSTRACT Hypertension is a major contributor to cardiovascular diseases, being the most common comorbidity and the biggest risk factor in heart failure with preserved ejection fraction. Angiotensin II (Ang II) is a known hypertension and heart failure inducer in mice, but its role in the causality in phenotype development remains unclear.
Diana Törmä +5 more
wiley +1 more source
HDAC6 modulates myofibril stiffness and diastolic function of the heart
The Journal of Clinical Investigation, 2022 Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Ying-Hsi Lin +18 more
doaj +1 more source
STUDI PEMBUATAN MINUMAN HERBA KELOPAK BUNGA ROSELA \ud (Hibiscus sabdariffa) :KAJIAN BENTUK POTONGAN DAN TIPE \ud PENGERING [PDF]
, 2007 Indonesia have tropical climate and most of that fertile the land is generate natural \ud resources that able to be innovated. Among natural resources that able to be innovated is \ud kind of plant wich have medicine or supplement content.
Nurhidayati, Titin
core
The FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen +15 more
wiley +1 more source