Results 11 to 20 of about 62,626 (262)

C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness

JCI Insight, 2020
Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility.
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn   +11 more
doaj   +2 more sources

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]

, 2018
Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa, Boknik, Peter, Dos Remedios, Cris G, Gergs, Ulrich, Hamdani, Nazha, Krysiak, Judith, Linke, Wolfgang A, Redfield, Margaret M, Sheikh, Farah, Unger, Andreas, von Frieling-Salewsky, Marion   +10 more
core   +5 more sources

Titin: roles in cardiac function and diseases

Frontiers in Physiology
The giant protein titin is an essential component of muscle sarcomeres. A single titin molecule spans half a sarcomere and mediates diverse functions along its length by virtue of its unique domains. The A-band of titin functions as a molecular blueprint
Dawson Stroik, Dawson Stroik, Zachery R. Gregorich, Farhan Raza, Ying Ge, Wei Guo, Wei Guo   +6 more
doaj   +2 more sources

Serum titin/creatinine ratio as a biomarker for discriminating disease severity in Duchenne and Becker muscular dystrophies [PDF]

Frontiers in Neurology
IntroductionDuchenne/Becker muscular dystrophies (DMD/BMD) are inherited muscle diseases, collectively referred to as dystrophinopathy, which are characterized by progressive degeneration or loss.
Yoshinori Nambu, Kayo Osawa, Taku Shirakawa, Aiko Sunami, Shoko Sonehara, Ryosuke Bo, Kandai Nozu, Masafumi Matsuo, Hiroyuki Awano   +8 more
doaj   +2 more sources

Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

Nature Communications, 2020
Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt   +10 more
doaj   +2 more sources

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM).
Beatrice Vahle, Antje Schauer, Antje Augstein, Maria‐Elisa Prieto Jarabo, Janet Friedrich, Peggy Barthel, Anita Männel, Norman Mangner, Siegfried Labeit, T. Scott Bowen, Axel Linke, Volker Adams   +11 more
doaj   +2 more sources

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

eLife, 2023
Sarcomeres are the force-producing units of all striated muscles. Their nanoarchitecture critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z-disc to the M-band and hence links actin and myosin filaments stably ...
Florian Schueder, Pierre Mangeol, Eunice HoYee Chan, Renate Rees, Jürgen Schünemann, Ralf Jungmann, Dirk Görlich, Frank Schnorrer   +7 more
doaj   +2 more sources

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Nature Communications, 2018
A family history of atrial fibrillation constitutes a substantial risk of developing the disease, however, the pathogenesis of this complex disease is poorly understood.
Gustav Ahlberg, Lena Refsgaard, Pia R Lundegaard   +2 more
exaly   +2 more sources

Truncations of Titin Causing Dilated Cardiomyopathy

New England Journal of Medicine, 2012
Daniel S Herman, Lien Lam, Matthew R G Taylor   +2 more
exaly   +2 more sources

Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix

Nature Cardiovascular Research, 2023
Myocardial passive stiffness is crucial for the heart’s pump function and is determined by mechanical elements, including the extracellular matrix and cytoskeletal filaments; however, their individual contributions are controversially discussed and ...
Christine M. Loescher, Johanna K. Freundt, Andreas Unger, A. Hessel, Michel Kühn, Franziska Koser, Wolfgang A. Linke   +6 more
semanticscholar   +1 more source