Results 21 to 30 of about 62,626 (262)
Biomedicines, 2023 Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction (NJ) of skeletal muscles. The major MG autoantigen is nicotinic acetylcholine receptor.
Christos Stergiou +13 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Skeletal and cardiac myopathies are often associated with mutations in the giant, cytoskeleton protein titin, but the role of titin during contraction at physiological sarcomere length is not known.
Caterina Squarci +10 more
semanticscholar +1 more source
Titin (TTN): from molecule to modifications, mechanics, and medical significance
Cardiovascular Research, 2021 The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and disease, which aids in the regulation of myocardial function, including ...
Christine M. Loescher +2 more
semanticscholar +1 more source
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The control scheme for length-dependent activation (LDA), a fundamental, striated muscle property where submaximal contraction is improved at longer compared to shorter lengths, is poorly understood. We demonstrate that 50% titin cleavage in
A. Hessel +8 more
semanticscholar +1 more source
Truncated titin proteins in dilated cardiomyopathy
Science Translational Medicine, 2021 Description Truncating mutations in TTN result in both truncated titin proteins and reduced full-length titin in patient hearts. Tracking titin in dilated cardiomyopathy Truncating variants in TTN, the gene encoding the titin protein, underlie 15 to 25 ...
Q. McAfee +14 more
semanticscholar +1 more source
Effect of titin phosphorylation on degradation of titin from skeletal muscles
Food Science and Human Wellness, 2023 The degradation of titin could make the myofibrillar fragmentation to improve meat tenderization during postmortem. This study aimed to investigate effect of phosphorylation on titin degradation.
Ying Wang +5 more
doaj +1 more source
bioRxiv, 2022 Sarcomeres are the force producing units of all striated muscles. Their nanoarchitecture critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z-disc to the M-band and hence links actin and myosin filaments stably ...
F. Schueder +7 more
semanticscholar +1 more source
Microbial production of megadalton titin yields fibers with advantageous mechanical properties
Nature Communications, 2021 Manmade high-performance polymers are typically non-biodegradable and derived from petroleum feedstock through energy intensive processes involving toxic solvents and byproducts.
C. H. Bowen +10 more
semanticscholar +1 more source
Scientific Reports, 2023 This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung
Masatoshi Hanada +12 more
doaj +1 more source
Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations. [PDF]
PLoS Computational Biology, 2016 Passive forces in sarcomeres are mainly related to the giant protein titin. Titin's extensible region consists of spring-like elements acting in series.
Gudrun Schappacher-Tilp +3 more
doaj +1 more source