Results 31 to 40 of about 62,626 (262)

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics

Redox Biology, 2022
Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key role in diastolic function and is a determinant factor in the etiology of heart disease.
Elías Herrero-Galán, Inés Martínez-Martín, Cristina Sánchez-González, Natalia Vicente, Elena Bonzón-Kulichenko, Enrique Calvo, Carmen Suay-Corredera, Maria Rosaria Pricolo, Ángel Fernández-Trasancos, Diana Velázquez-Carreras, Claudio Badía Careaga, Mahmoud Abdellatif, Simon Sedej, Peter P. Rainer, David Giganti, Raúl Pérez-Jiménez, Jesús Vázquez, Jorge Alegre-Cebollada   +17 more
doaj   +1 more source

Post-training urinary titin fragment concentration increases in athletes with previous muscle strain injury: a pilot study in soccer players

Journal of Physical Fitness and Sports Medicine, 2021
Urinary titin fragment concentration has been established as a noninvasive biomarker of muscle protein degradation and muscle damage after exercise. We hypothesized that concerning the microdamage in the chronic phase of muscle strain injury, muscle ...
Tomonori Kawai, Koichi Takamoto, Itsumu Bito   +2 more
doaj   +1 more source

Use of animal models to understand titin physiology and pathology

Journal of Cellular and Molecular Medicine, 2022
In recent years, increasing attention has been paid to titin (TTN) and its mutations. Heterozygous TTN truncating variants (TTNtv) increase the risk of a cardiomyopathy.
Matteo Marcello, Viviana Cetrangolo, M. Savarese, B. Udd   +3 more
semanticscholar   +1 more source

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy [PDF]

, 2015
Frameshift mutations in the TTN gene encoding titin are a major cause for inherited forms of dilated cardiomyopathy (DCM), a heart disease characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure. To date, there are no
Alessandra, Moretti, Alexander, Goedel, Annemieke Aartsma, Rus, Brenda, Gerull, Daniel, Sinnecker, Elvira, Parrotta, John J., Atherton, Julie, Mcgaughran, Karl Ludwig, Laugwitz, Katja, Metzger, Ludwig, Thierfelder, Luna Simona, Pane, Martin, Schaller, Matthias, Mann, Meinrad Paul, Gawaz, Michael, Gramlich, Murgia, Marta, Qifeng, Zhou, Richard P., Harvey, Siegfried, Labeit, Sonja, Sch\uf6tterl, Thomas, Brade, Zhifen, Chen   +22 more
core   +1 more source

Microstructural analysis of skeletal muscle force generation during aging. [PDF]

, 2020
Human aging results in a progressive decline in the active force generation capability of skeletal muscle. While many factors related to the changes of morphological and structural properties in muscle fibers and the extracellular matrix (ECM) have been ...
Basava, Ramya R, Chen, Jiun-Shyan, He, Qizhi, He, Xiaolong, Hodgson, John, Sinha, Shantanu, Sinha, Usha, Zhang, Yantao   +7 more
core   +1 more source

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]

, 2019
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide, Bard, Bard, Bard, Bashore, Beckwith, Dambacher, de la Peña, Ding, Dong, Eisele, Elsasser, Finley, Glickman, Glickman, Goldstein, Groll, Hershko, Kachroo, Lander, Lasker, Longtine, Matyskiela, Myers, Nemec, Peth, Prakash, Rubin, Smith, Sone, Tomko, Unverdorben, Verma, VerPlank, VerPlank, Wehmer, Wendler, Wenzel, Worden, Worden, Yao, Zhu, Śledź   +42 more
core   +1 more source

Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring

International Journal of Molecular Sciences, 2022
Muscular dystrophy with myositis (mdm) is a naturally occurring mutation in the mouse Ttn gene that results in higher passive stress in muscle fibers and intact muscles compared to wild-type (WT).
P. Hettige, Dhruv Mishra, H. Granzier, K. Nishikawa, Matthew J. Gage   +4 more
semanticscholar   +1 more source

Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin

Journal of Cellular and Molecular Medicine, 2021
N6‐methyladenosine (m6A) is the most prevalent modification in mRNA and engages in multiple biological processes. Previous studies indicated that m6A methyltransferase METTL3 (‘writer’) and demethylase FTO (‘eraser’) play critical roles in heart‐related ...
Siyun Gao, Haifeng Sun, Kejing Chen, Xueying Gu, Hongyu Chen, Liudan Jiang, Lei Chen, Shengqi Zhang, Yi Liu, Dan Shi, Dandan Liang, Liang Xu, Jian Yang, Yanjiao Ruan, Hao Chen, Bin Shen, Honghui Ma, Yi-Han Chen   +17 more
semanticscholar   +1 more source

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences [PDF]

, 2009
Background: Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction.
AM Katz, AN Tintu, Andrei Tintu, Anne Cathrine Staff, Arnold Schwartz, Asif Ahmed, BO Verburg, C Holubarsch, CP Leeson, DE Stewart, DJ Barker, E Villamor, EA Dumont, Edgar Hernandez-Andrade, Eduard Gratacos, Ellen Rouwet, Erdal Safak, EV Rouwet, Fatima Crispi, Ferdinand le Noble, FJ Giordano, G Pardi, H Haase, H Sugimoto, HQ Miao, I Shiojima, Ingo Morano, Irene Cetin, J Schaper, JL Morrison, Joep Brinkmann, JR Ingelfinger, KH Nicolaides, L Miquerol, L van Heerebeek, Leo Hofstra, M Feucht, M Ream, Marc Tjwa, Marc van Bilsen, Michael Jacobs, MR Zile, MR Zile, MW Gillman, N Ferrara, P Carmeliet, Peter Carmeliet, R Tatsumi, S Gupta, S Hein, S Hein, S Louey, SF Nagueh, Shakil Ahmad, SK Sharma, Stefan Verlohren, TA Fong, TM Nosek, Wouter H. Lamers, X Yue, Y Dor, Y Sugishita, Y Wu   +62 more
core   +8 more sources

Detection and quantification of the giant protein titin by SDS-agarose gel electrophoresis

MethodsX, 2017
Titin, a giant sarcomeric protein, is involved in the generation of passive tension during muscle contraction, assembly and stability of the sarcomere in striated muscles. Titin gene produces numerous titin protein isoforms with different sizes (∼3–4 MDa)
Chaoqun Zhu, Wei Guo
doaj   +1 more source