Results 41 to 50 of about 62,626 (262)

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere

EMBO Reports, 2021
Striated muscle undergoes remodelling in response to mechanical and physiological stress, but little is known about the integration of such varied signals in the myofibril. The interaction of the elastic kinase region from sarcomeric titin (A168‐M1) with
J. Bogomolovas, J. Fleming, B. Franke, B. Manso, B. Simon, A. Gasch, Marija Markovic, T. Brunner, R. Knöll, Ju Chen, S. Labeit, M. Scheffner, C. Peter, O. Mayans   +13 more
semanticscholar   +1 more source

Urinary Titin Is Increased in Patients After Cardiac Surgery

Frontiers in Cardiovascular Medicine, 2019
Background: Few non-invasive biomarkers have been used to detect myocardial injury in patients with heart diseases. Recently, the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, which is involved in muscular passive tension and ...
Jun Tanihata, Naritomo Nishioka, Naritomo Nishioka, Takahiro Inoue, Ko Bando, Susumu Minamisawa   +5 more
doaj   +1 more source

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]

, 2012
Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju, Lange, Stephan, Perera, Sue, Teh, Phildrich   +3 more
core   +2 more sources

Genetic Landscape of Oral Cavity Squamous Cell Carcinoma. [PDF]

OTO Open
Abstract Objective The association, if any, between gene mutations, pathologic features of squamous cell carcinoma of the head and neck, and patient prognosis is unknown. This study investigates the association between common gene mutations in oral cavity squamous cell carcinoma, pathologic features of malignancy, and patient survival.
Celidonio J, Chinta S, de Armas JS, Roden D.   +3 more
europepmc   +2 more sources

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator

The Journal of General Physiology, 2021
Passive force generated in titin plays an important role in maintaining sarcomere structure. In this paper, van der Pijl et al. describe a mechanism by which muscle ankyrin repeat protein 1 (MARP1) locks titin to the thin filament to increase passive ...
Robbert J. van der Pijl, Marloes van den Berg, Martijn van de Locht, Shengyi Shen, S. Bogaards, S. Conijn, P. Langlais, P. Hooijman, S. Labeit, L. Heunks, H. Granzier, C. Ottenheijm   +11 more
semanticscholar   +1 more source

Titin mutation associated with responsiveness to checkpoint blockades in solid tumors.

JCI Insight, 2019
Immune checkpoint blockade (ICB) immunotherapy induces potent antitumor immunity across multiple solid tumors, although few patients respond well to this therapy.
Q. Jia, Jun Wang, N. He, Ji He, B. Zhu
semanticscholar   +1 more source

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant

Basic Research in Cardiology, 2021
Titin truncating variants are a well-established cause of cardiomyopathy; however, the role of titin missense variants is less well understood. Here we describe the generation of a mouse model to investigate the underlying disease mechanism of a ...
He Jiang, C. Hooper, M. Kelly, V. Steeples, Jillian N. Simon, Julia Beglov, A. Azad, Lisa Leinhos, P. Bennett, E. Ehler, J. Kalisch-Smith, D. Sparrow, R. Fischer, R. Heilig, H. Isackson, M. Ehsan, Giannino Patone, N. Huebner, B. Davies, H. Watkins, K. Gehmlich   +20 more
semanticscholar   +1 more source

The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles

Biophysical Reviews, 2021
Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc.
Robbert J. van der Pijl, A. Domenighetti, F. Sheikh, E. Ehler, C. Ottenheijm, S. Lange   +5 more
semanticscholar   +1 more source

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and western blotting comparisons of purified myofibrils and whole muscle preparations for evaluating titin and nebulin in postmortem bovine muscle [PDF]

, 1996
Purified myofibril (MF) and homogenized whole muscle (WM) samples were prepared from A maturity market steers. Samples were removed at 0, 1, 3, 7, 14, and 28 d postmortem.
Huff-Lonergan, Elisabeth, Huff-Lonergan, Elisabeth, Mitsuhashi, Tomiko, Parrish, Frederick, Robson, Richard   +4 more
core   +3 more sources

Titin‐based mechanosensing modulates muscle hypertrophy

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Titin is an elastic sarcomeric filament that has been proposed to play a key role in mechanosensing and trophicity of muscle. However, evidence for this proposal is scarce due to the lack of appropriate experimental models to directly test the
Robbert van derPijl, Joshua Strom, Stefan Conijn, Johan Lindqvist, Siegfried Labeit, Henk Granzier, Coen Ottenheijm   +6 more
doaj   +1 more source