Results 71 to 80 of about 62,626 (262)

3D‐Printed Protein Models as an Educational Tool in Biochemistry Outreach

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT The abstract and complex nature of molecular biology often presents significant challenges for students at all levels of study. Traditional teaching methods, such as the use of 2D diagrams, may not fully convey the intricacies of these topics, leading to difficulties in comprehension and engagement. This study aimed to introduce 3D‐printed and
Oliver Osborne, Siobhan Clennell, Shaun K. Bremner‐Hart   +2 more
wiley   +1 more source

Aortic stenosis and aortic regurgitation express different titin isoforms: Differences and relationships with functional and geometric characteristics [PDF]

, 2018
Background-Titin represents an important biomechanical sensor which determines compliance and diastolic/ systolic function of the left ventricle (LV). To assess the different titin-isoform expression and the relationships with functional and geometric ...
Antignano, Anita, De Amicis, Vincenzo, Iannelli, Gabriele, Mannacio, Luigi, Mannacio, Vito, Musumeci, Francesco   +5 more
core   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

Journal of Translational Medicine, 2012
Background Titin is a muscle-specific protein found in cardiac and skeletal muscles which is responsible for restoring passive tension. Levels and functioning of titin have been shown to be affected by cardiac damage.
Vassiliadis Efstathios, Rasmussen Lars M, Byrjalsen Inger, Larsen Dorthe, Chaturvedi Rajiv, Hosbond Susanne, Saabye Lotte, Diederichsen Axel CP, Genovese Federica, Duffin Kevin L, Zheng Qinlong, Chen Xiaoliang, Leeming Diana J, Christiansen Claus, Karsdal Morten A   +14 more
doaj   +1 more source

Mechanical Stretching of Proteins: Calmodulin and Titin

, 2004
Mechanical unfolding of several domains of calmodulin and titin is studied using a Go-like model with a realistic contact map and Lennard-Jones contact interactions.
Abe, Banavar, Bernstein, Bockelmann, Carrion-Vasquez, Carrion-Vazquez, Carrion-Vazquez, Cieplak, Cieplak, Cieplak, Cieplak, Cieplak, Cieplak, Cluzel, Du, Florin, Fowler, Grubmuller, Guan, Hoang, Hoang, Improta, Janovjak, Kellermayer, Lu, Marek Cieplak, Maritan, Marszalek, Micheletti, Plaxco, Plaxco, Rief, Settanni, Smith, Takada, Tsai, Tskhovrebova, Unger, Veitshans, Yang   +39 more
core   +1 more source

Titin as a force-generating muscle protein under regulatory control.

Journal of applied physiology, 2019
Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres.
Johanna K. Freundt, W. Linke
semanticscholar   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Titin oxidation alters titin stiffness, which greatly contributes to overall myocardial stiffness. This stiffness is frequently increased in heart disease, such as diastolic heart failure.
Christine M. Loescher, Martin Breitkreuz, Yong Li, A. Nickel, A. Unger, Alexander Dietl, A. Schmidt, Belal A. Mohamed, S. Kötter, J. Schmitt, Marcus Krüger, Martina Krüger, K. Toischer, C. Maack, L. Leichert, N. Hamdani, W. Linke   +16 more
semanticscholar   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1485-1489, April 2025.
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Sanjay Divakaran, Vinay Randhawa, Usman A. Tahir, Matthew Robertson, Anam A. Waheed, Anna Perillo, Leanne Barrett, Ron Blankstein, Mark W. Feinberg, Marcelo F. Di Carli, Neal K. Lakdawala   +10 more
wiley   +1 more source

Evolution of the Highly Repetitive PEVK Region of Titin Across Mammals

G3: Genes, Genomes, Genetics, 2019
The protein titin plays a key role in vertebrate muscle where it acts like a giant molecular spring. Despite its importance and conservation over vertebrate evolution, a lack of high quality annotations in non-model species makes comparative evolutionary
Kathleen Muenzen, Jenna Monroy, Findley R. Finseth   +2 more
doaj   +1 more source