Results 131 to 140 of about 17,805,524 (287)

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

بررسی تأثیر ابتلا به پریودنتیت مزمن بر میزان بیان ژن TLR-2 و TLR-4 در بافت لثه ای [PDF]

Journal of Mashhad Dental School, 2011
مقدمه: در عفونت‏های پریودنتال پیش نیاز شروع پاسخ‏های میزبان، شناخت پاتوژن‏‏ها توسط سیستم ایمنی میزبان می‏باشد. خانواده رسپتور‏های Toll-like (TLRs)، مسئول شناسایی ساختار‏های حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتری‏ها می‏باشند و مسیر‏های سیگنال
کاظم فاطمی, مهرداد رادور, عبدالرحیم رضایی, حمیدرضا عرب, هوشنگ رفعت پناه, حسن آذان گو خیاوی, یلدا دادپور   +6 more
doaj  

Cost analysis of target lesion revascularisation in patients with femoropopliteal in stent re-stenosis or occlusion : the COSTLY-TLR study [PDF]

Objective: To report the cost of target lesion revascularisation procedures (TLR) for femoropopliteal peripheral artery disease (PAD) following stenting, from a healthcare payer's perspective.
Gianluigi, Fino, Konstantinou, Nikolaos, Isernia, Giacomo, Nikolaos Tsilimparis, Messeder, Sarah J., Mercedes Guerra Requena, Stefano Fazzini, Coscas, Raphael, Gordillo, Sergio, Valdivia, Andrés Reyes, D'Oria, Mario, Chisci, Emiliano, Lepidi, Sandro, Patel, Bhavisha, Nikolaos Konstantinou, Ryan Gouveia E Melo, Torsello, Giovanni B., Zayed, Hany, Uijtterhaeghen, Gilles, COSTLY-TLR Collaborators, Gilles Uijtterhaeghen, Tsilimparis, Nikolaos, Messeder, Sarah J, Mario D'Oria, Sandro Lepidi, Torsello, Giovanni F., Torsello, Giovanni F, Cardona-Gloria, Yamel, Van Herzeele, Isabelle, Fino Gianluigi, Stavroulakis, Konstantinos, Nicola Troisi, Fazzini, Stefano, Guerra Requena, Mercedes, Saratzis, Athanasios, Bhavisha Patel, Troisi, Nicola, e Melo, Ryan Gouveia, COSTLY-TLR Collaborators, [missing], Sergio Gordillo, Torsello, Giovanni B, Raphael Coscas, Andrés Reyes Valdivia   +42 more
core   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Тhe prevalence of TLR-2, TLR-3, TLR-4 genes polymorphism in patients with complicated grippe course and its effect estimation on grippe-associated pneumonia course

, 2013
Метою цього дослідження було вивчити поширеність та оцінити вплив поліморфізму генів Arg753Gln TLR-2, Leu412Рhe TLR-3, Asp299Gly TLR-4 на перебіг грип-асоційованої пневмонії. В групу здорових осіб увійшли 148 мешканців Полтавської області та 46 хворих на
Pryimenko, N. O., Прийменко, Наталія Олегівна, Прийменко, Наталья Олеговна   +2 more
core   +1 more source

Relationship between TLR-2 level and clinical or radiological severity on patients with tuberculosis spondylitis in Dr. Wahidin Sudirohusodo hospital Makassar. [PDF]

Medicine (Baltimore), 2023
Arifin J, Saleh MR, Argo RS, Kennedy D, Usman MA, Singjie LC.   +5 more
europepmc   +1 more source

Increased plasma microbial tDR‐1 in at‐risk individuals is associated with decreased conversion to clinical rheumatoid arthritis and reduces an in vitro macrophage type 1 interferon response

Arthritis &Rheumatology, Accepted Article.
Background Microbial small RNAs (sRNAs) can regulate human genes. Higher plasma concentrations of microbial tRNA‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anti‐cyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (ARI)
Anastasiia Phothisane, Tulsi K Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L Feser, Jill M Norris, M Kristen Demoruelle, LauraKay Moss, Kevin D Deane, V Michael Holers, Michelle J Ormseth   +11 more
wiley   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

TNF-α and IL-6 Cytokine Production from TLR-2 and TLR-4 Stimulated Splenocytes Post-Spaceflight.

, 2015
Data obtained by ELISA, from Zymosan (TLR-2 agonist; 10μg/ml) or LPS (TLR-4 agonist; 200ng/mL) stimulated splenocytes from post-spaceflight (Flight) mice or animal enclosure module (AEM) ground control mice.
Jeffrey K. Actor (413603), Shen-An Hwang (738245), Brian Crucian (31392), Clarence Sams (31398)   +3 more
core   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source