International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson +8 more
wiley +1 more source
Targeting dendritic cells with TLR-2 ligand-coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity. [PDF]
J Biol Chem, 2022 Kumar Das D +11 more
europepmc +1 more source
FREQUENCY OF TLR-2, 4, 9 AND CD14 POLYMORPHISMS IN AGGRESSIVE PERIODONTITIS POPULATION IN AFRICAN-AMERICANS [PDF]
, 2009 Aim: The aim of this study is to determine the frequency of single nucleotide polymorphisms (SNPs) in various pattern recognition receptor (PRR) genes, including Toll like receptors (TLR) -2, -4, -9, and CD14 in chronic (CP), localized (LAP) and ...
Chou, Melanie
core +1 more source
Animal Models and Experimental Medicine, EarlyView.The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li +9 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
支气管肺泡灌洗液及血清NF-κB、TLR-2、TLR-4、 TNF-α在肺炎诊断中的应用价值
Zhongguo shiyan zhenduanxue目的 探讨支气管肺泡灌洗液(BALF)及血清核转录因子-κB(NF-κB)、Toll样受体2(TLR-2)、Toll样受体4(TLR-4)、肿瘤坏死因子α(TNF-α)在肺炎诊断中的应用价值。方法 选取2023年1月—2024年3月于吉林大学第二医院就诊的57例肺炎患者纳入研究组，另取同期体检的健康者57例纳入对照组，均采集外周静脉血与肺泡灌洗液，检测NF-κB、TLR-2、TLR-4、TNF-α水平，采用Pearson相关性分析患者血清及BALF中NF-κB、TLR-2、TLR-4、TNF-α的相关性。
金美玉, 王冠, 林文婷, 吴艳峰
doaj
The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the TLR-2/NF-κB signaling pathway through suppressing cellular senescence. [PDF]
Bioeng Transl Med, 2023 Zhang C +7 more
europepmc +1 more source
Polymorphic variants of the TLR 2 gene in syphilis [PDF]
Medical news of the North Caucasus, 2017 Lyudmila Barycheva +3 more
openaire +1 more source
TLR-1, TLR-2, and TLR-6 MYD88-dependent signaling pathway: A potential factor in the interaction of high-DNA fragmentation human sperm with fallopian tube epithelial cells. [PDF]
Clin Exp Reprod Med, 2023 Zandieh Z +7 more
europepmc +1 more source
Physical Activity Maintain Immune Response Through TLR-2/TLR-4 Gene Expression in Type-2 Diabetes Mellitus Patient at Medan City. [PDF]
Med Arch, 2023 Machrina Y +4 more
europepmc +1 more source