Results 101 to 110 of about 11,832,408 (324)

Toll-like receptors TLR-2, TLR-4, TLR-7, and TLR-9 in tumor tissue and serum of the patients with esophageal squamous cell carcinoma and gastro-esophageal junction cancer.

Advances in Clinical and Experimental Medicine, 2018
BACKGROUND Stimulation of toll-like receptors (TLRs) has been linked to the development of esophageal and gastric cancers. OBJECTIVES The aim of the study was to evaluate the clinical significance of tissue expression and serum concentration of TLR-2 ...
D. Diakowska, M. Nienartowicz, K. Grabowski, J. Rosińćzuk, M. Krzystek-Korpacka   +4 more
semanticscholar   +1 more source

Streptococcus bovis Contributes to the Development of Colorectal Cancer via Recruiting CD11b+TLR-4+ Cells

Medical Science Monitor, 2020
Background An increasing number of studies have demonstrated that Streptococcus bovis and its concomitant inflammatory factors concentrate in the intestine in colorectal cancer (CRC). However, the molecular mechanism of S.
Q. Deng, Chang-Jian Wang, Kailin Yu, Yahui Wang, Qinyan Yang, Jingjing Zhang, Xiaoping Xu   +6 more
semanticscholar   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide [PDF]

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core   +1 more source

Probing Cellular Activity Via Charge‐Sensitive Quantum Nanoprobes

Advanced Materials, EarlyView.
A new quantum sensing modality detects shifts in zero‐field splitting caused by charge rearrangement with diamond nanocrystals in response to cellular activity. These electric‐field‐driven effects provide an alternative to temperature‐based interpretations, enabling real‐time, single‐cell readout of inflammation.
Uri Zvi, Shivam Mundhra, David Ovetsky, Qing Chen, Aidan R. Jones, Stella Wang, Maria J. Román‐Vazquez, Marie Kim, Udoka M. Ibeh, Michele Ferro, Kunle Odunsi, Marina C. Garassino, Michael E. Flatté, Melody A. Swartz, Denis R. Candido, Aaron Esser‐Kahn, Peter C. Maurer   +16 more
wiley   +1 more source

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype [PDF]

Journal of Leukocyte Biology, 2011
ABSTRACTEicosanoid metabolism differs in profile and quantity between macrophages of different tissue origin and method of elicitation, as well as between primary and immortalized macrophages after activation with inflammatory stimuli. Using a lipidomic approach, we comprehensively analyzed the eicosanoids made by murine RPMs, TGEMs, BMDM, and the ...
Norris, Paul C, Reichart, Donna, Dumlao, Darren S, Glass, Christopher K, Dennis, Edward A   +4 more
openaire   +4 more sources

Role of TLR-4 in anti-β2-glycoprotein I-induced activation of peritoneal macrophages and vascular endothelial cells in mice

Molecular Medicine Reports, 2019
Anti-phospholipid syndrome (APS) is a systematic autoimmune disease that is associated with presence of antiphospholipid antibodies (aPL), recurrent thrombosis, and fetal morbidity in pregnancy.
Meiyun Wang, X. Kong, Yachao Xie, Chao He, Ting Wang, Hong Zhou   +5 more
semanticscholar   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Aggregation Behavior of an Ultra-Pure Lipopolysaccharide that Stimulates TLR-4 Receptors [PDF]

Biophysical Journal, 2008
The innate immune systems of humans and other animals are activated by lipopolysaccharides (LPS), which are glucosamine-based phospholipids that form the outer leaflet of the outer membranes of Gram-negative bacteria. Activation involves interactions of LPS with the innate immunity-receptor comprised of toll-like receptor 4 in complex with so-called MD-
Sasaki, Hirotaka, White, Stephen H
openaire   +3 more sources

Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation of AMPK could inhibit LPS-induced Tlr-4 gene expression in ...
Maryam Rameshrad, Nasrin Maleki-Dizaji, Hamid Soraya, Negisa Seyed Toutounchi, Abolfazl Barzegari, Alireza Garjani   +5 more
doaj   +1 more source

Superoxide induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism

Molecular Medicine, 2016
Neutrophils constitute the early innate immune response to perceived infectious and sterile threats. Neutrophil extracellular traps (NETs) are a novel mechanism to counter pathogenic invasion and sequelae of ischemia, including cell death and oxidative ...
A. B. Al-Khafaji, S. Tohme, H. Yazdani, David C. Miller, Hai Huang, A. Tsung   +5 more
semanticscholar   +1 more source